尿囊素的合成研究

Research on the Synthesis of Allantoin

提出了一种合成尿囊素的新方法。以乙二醛为原料 ,采用杂多酸—磷钨酸做催化剂 ,先用过氧化氢做氧化剂氧化制得乙醛酸 ,再与尿素直接缩合生成尿囊素 ,总收率可达 5 8.6%。研究了氧化反应温度、催化剂用量对尿囊素产率的影响。确定了最佳工艺条件 :( 1) 40 %乙二醛水溶液 72 .4g ,3 0 %过氧化氢水溶液 62 .3g ,磷钨酸 0 .2 5 g ,在 5± 2℃下 ,搅拌反应 5～ 6h ;( 2 )尿素 96g ,在75～ 80℃之间 ,搅拌反应 2h。

A new method of synthesizing allantoin was proposed.First glyoxalic acid was prepared by using glyoxal as material?FTA- Phosphotungstic acid as efficient catalyst and hydrogen peroxide as oxidant.Then allantoin was making by condensing glyoxalic acid and urea directly,which the yield of allantoin can reach 58.6%.The effect of oxidation reaction temperature and catalyst dosage on the yield of allantoin was researched and the optimum process conditions was confirmed (1)40% glyoxal solution 72.4g,30% hydrogen peroxide solution 62.3g,phosphotungstic acid 0.25g,under the temperature of 5±2℃,stirring react 5～6h.(2)urea 96g,between the temperature of 75～80℃,stirring react 2h.