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重组人骨形成蛋白-2的研究进展 被引量：3

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摘要 重组人骨形成蛋白 - 2能诱导骨形成、促进骨折愈合 ,不同的剂量、不同的部位等因素对重组人骨形成蛋白的成骨能力不同。
作者 周鑫才 李祖兵
机构地区 武汉大学口腔医学院口腔颌面外科
出处 《口腔医学》 CAS 2004年第3期178-179,共2页 Stomatology
关键词 重组人骨形成蛋白-2 骨形成 骨折愈合
分类号 R341.9 [医药卫生—基础医学]
  • 相关文献

参考文献18

  • 1Marukawa E, Asahina I, Oda M, et al. Bone regeneration using recombinant human bone morphogenetic protein-2(rhBMP-2) in alveolar defects of primate mandibles [J]. Br J Oral Maxillofac Surg ,2001,39(6): 452 - 459.
  • 2BoynePJ, NalamuraA , Shabahang S. Evaluation of the long-term effect of function on thBMP-2 regenerated hemimandibulectomy defects[J]. Br J Oral Maxillofac Surg, 1999,37(5) :344 - 352.
  • 3Nakagawa T, Sugiyama T, Kamei T, et al. An inmmno-light and electron-microscopic study of the expression of bone morphogenetic protein-2 during the process of ectopic bone formation in the rat [ J ].Archives of Oral Biology, 2001,46(5) :403 - 411.
  • 4Gordh M, Albertius P, Johnell O, et al. Effects of thBMP-2 and osteopromotive membrances on experimental bone grafting[ J]. Plast Reconstr Surg, 1999,103(7): 1909 - 1918.
  • 5Zellin G, Linde A. Bone neogenesis in domes made of expanded polytetrafluoroethylene efficacy of rhBMP-2 to enhance the amount of achievable bone in rats [J]. Plast Reconstr Surg, 1999,103(4): 1229- 1237.
  • 6Bouxsein ML, Turek TJ, Blake CA , et al. Recombinant human bone morphogenetic protein-2 accelerates healing in rabbit ulnar osteotomy model [J]. Bone Joint Surg Am, 2001,83(8):1219 - 1230.
  • 7Fujimura K, Bessho K, Kusmooto K, et al. Experimental osteoinduction by recombinant human bone morphogeneticprotein 2 in tissue with ow blood flow: a study in rats[J]. Br J Oral Maxillofac Surg , 2001,39(4) :294 - 300.
  • 8Alam I, Asahina I, Seto I, et al. Prefabricated vascularized bone flap:a tissue transformation technique for bone reconstruction [ J ].Plast Reconstr Surg, 2001,108(4) :952 - 958.
  • 9Tatakis DN, Koh A, Jin L, et al. Peri-implant bone regeneration using recombinant human bone morphogenetic protein-2 in a canine model: a dose-response study [J]. Periodont Res, 2002,37(2) :93 - 100.
  • 10Sero I, Asabina I, Oda M, et al. Reconstruction of the primate mandible with a combination graft of recombinant human bone morphogenetic protein-2 and bone marrow [J]. Oral Maxillofac Surg, 2001,59(1):53 -61.

二级参考文献3

共引文献6

同被引文献23

  • 1张秀白,刘宏伟,刘兴文,李毅.磷酸三钙与珊瑚羟磷灰石细胞相容性的实验研究[J].口腔医学,2004,24(3):132-134. 被引量：5
  • 2周印锁,王思远,吴健红.中药地榆粉末显微鉴定研究[J].中国药学杂志,1995,30(1):3-7. 被引量：3
  • 3Kawamura M, Urist MR. Human fibrin is a physiologic delivery system for bone morphogenetic protein [J]. Clin Orthop, 1988, 235(2):302- 309.
  • 4Yasuda H,Shima N,Nakagawa N,et al.Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG):A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro[J].Endocrinology,1998,139(3):1329-1337.
  • 5Bhattacharyya RS, Stem PH. IGF-I and MAP kinase involvement in the stimulatory effects of LNCaP prostate cancer cell conditioned media on cell proliferation and protein synthesis in MC3T3-E1 osteoblastic cells[J] .J Cell Biochem, 2003,90(5) :925 - 937.
  • 6Boguslawski G,Hale LV, Yu XP, et al. Activation of osteocalcin transcription involves interaction of protein kinase A-and protein kinase Cdependent pathways[J] .J Biol Chem,2000,275(2) :999- 1006.
  • 7Spinella-Jaegle S, Poman-Roman S, Faucheu C, et al. Opposite effects of bone morphogenetic protein-2 and transforming growth faetor-β1 on osteoblast differentiation[J].Bone,2001,29(4):323 - 330.
  • 8Guicheux J, Lemonnier J, Ghayor C, et al. Activation of p38 mitogenactivated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation [J] .J Bone Miner Res,2003,18(11):2060-2068.
  • 9Takagi M,Kamiya N,Takahashi T,et al. Effects of bone morphogenetic protein-2 and transforming growth faetor betal on gene expression of transcription factors, AJ18 and Runx2 in cultured osteoblastie cells[J].J Mol Histol,2004,35(1):81-90.
  • 10Van den Dolder J,de Ruijter AJ,Spauwen PH, et al. Observations on the effect of BMP-2 on rat bone marrow cells cultured on titanium substrates of different foulness[J]. Biomaterials, 2003,24 (11):1853 -1860.

引证文献3

二级引证文献11

口腔医学
2004年 第3期

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