VEGF测定在急性心肌梗死中的意义

Relationship between the levels of serum vascular endothelial growth factor and acute myocardial infarction

目的探讨急性心肌梗死(AMI)患者血清血管内皮生长因子(VEGF)含量的变化及意义。方法观察16例AMI患者经过冠状动脉成型术,以及肝素、硝酸酯类药物、阿斯匹林等治疗前后血清VEGF的变化。于发病第1、3、14d和28d分别测定血清VEGF的含量。结果发病后第1 d血清VEGF的浓度与对照组无显著差别(85±11)vs(72±2)pg/mL(P>0.05)。发病后第3 d,VEGF的浓度较第1 d明显升高(150±46)vs(85±11)pg/mL(P<0.001)。发病后第7 d达高峰(171±31)vs(85±11)pg/mL(P<0.0001)。之后开始下降,但第28 d仍明显高于第1 d(142±132)vs(85±11)pg/mL(P<0.001)。结论AMI治疗后VEGF的水平明显持续增高,可能与缺血心肌的血管新生及冠状血管侧枝循环的建立有关。

Objective To evaluate the clinical significance of vascular endothelial growth factor (VEGF) during acute myocardial infarction (AMI). Methods Serum VEGF was measured in 16 AMI patients undergoing angio plasty and receiving medical treatment with heparin, isosorbide dinitrate, and aspirin. VEGF was measured on day 1,3,14 and 28 after occurrence of AMI. Results The serum VEGF levels of AMI patients were significantly elevated from day 3 (150±46) pg/mL(P < 0. 001) , to day 28 (142 ±132) pg/mL(P <0.001) , peaking on day 7 (171±31) pg/mL (P<0.0001) compared with day 1(85±11) pg/mL as a control group. Conclusion The levels of VEGF have significant changes after the onset of AMI. It may reflect the effects of myocardial angiogenesis and neovascularization.