摘要
十余年来人们对基因与心律失常的关系的认识有了长足的进步 ,许多遗传性心律失常的致病基因被发现 ,机理也得到阐明。本文对此作一简要而较为全面的综述 ,分析了基因与心律失常的关系 。
出处
《中国心脏起搏与心电生理杂志》
2004年第3期227-230,共4页
Chinese Journal of Cardiac Pacing and Electrophysiology
参考文献30
-
1Cheng CF, Kuo HC, Chien KR. Genetic modifiers of cardiac arrhythmias[J]. Trends Mol Med, 2003,9:59
-
2Keating M, Atkinson D, Dunn C,et al. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene[J]. Science, 1991,252:704
-
3Jiang C, Atkinson D, Towbin JA,et al. Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity[J]. Nat Genet, 1994,8:141
-
4Schott JJ, Charpentier F, Peltier S,et al. Mapping of a gene for long QT syndrome to chromosome 4q25-27[J]. Am J Hum Genet, 1995 ,57:1 114
-
5Mohler PJ, Schott JJ, Gramolini AO,et al. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death[J]. Nature, 2003,421:634
-
6Splawski I, Tristani-Firouzi M, Lehmann MH,et al. Mutations in the hminK gene cause long QT syndrome and suppress IKs function[J]. Nat Genet, 1997,17:338
-
7Abbott GW, Sesti F, Splawski I,et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia[J]. Cell, 1999,97:175
-
8Plaster NM, Tawil R, Tristani-Firouzi M,et al. Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome[J]. Cell, 2001,105:511
-
9Chen Q, Kirsch GE, Zhang D,et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation[J]. Nature, 1998,392:293
-
10Weiss R, Barmada MM, Nguyen T,et al. Clinical and molecular heterogeneity in the Brugada syndrome: A novel gene locus on chromosome 3[J]. Circulation, 2002,105:707
同被引文献22
-
1Hurtado Buen Abad L, Elizalde Galv6n A, C6rdenas M. Rhythm and conduction disorders in familial myocardiopathy [J]. Arch Inst Cardiol Mex, 1976 ,46 (3) :253.
-
2Lombardi F, Belletti S, Battezzati PM, et al. MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardiover- sion in patients with persistent atrial fibrillation [ J ]. J Cardiovasc Med (Hagerstown) , 2011,12(1) :37.
-
3Chen YH, Xu WJ, Bendahhou S, et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation[J].Science,2003,299:251.
-
4Katz AM. Cardiac ion channels [ J], N Engl J Med, 1993,328:1 244.
-
5Yang Y, Xia M, Jin Q, et al. Identification of a KCNE2 gain-of- functionmutation in patients with familial atrial fibrillation[ J]. Am J Hum Genet,2004,75:899.
-
6Xia M, Jin Q, Bendahhaou S, et al. A Kir2.1 gain-of-function mu- tation underlies familial atrial fibrillation[J]. Biochem Biophys Res Commun, 2005,332:1 012.
-
7Ravn LS, Aizawa Y, Pollevick GD, et al. Gain-of-function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation [J]. Heart Rhythm, 2008,5:427.
-
8Olson TM, Alekseev AE, Liu XK, et al. Kvl. 5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation [J]. Hum Mol Genet, 2006,15:2 185.
-
9Chen Q, Kirsch GE, Zhang D, et al. Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation [J]. Nature, 1998,392 : 293.
-
10Benson DW, Wang DW, Dyment M, et al. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium chan- nel gene (SCN5A)[J]. Clin Invest ,2003,112:1 019.
-
1龙怡道,章扬龙.长QT综合征[J].江西医药,1991,26(1):43-44.
-
2陈琪.长QT综合征[J].医学综述,1996,2(6):278-281. 被引量：1
-
3汪明慧,梁文同.长QT综合征的诊断和治疗[J].心血管病学进展,2003,24(2):155-157. 被引量：2
-
4李言让,沈际皋.长QT综合征——尖端扭转型室性心动过速[J].心血管病学进展,1993,14(3):148-152. 被引量：6
-
5李国锋.长QT综合征2例[J].美国中华临床医学杂志,2002,4(2):163-163.
-
6张萍,张萍,张萍,张萍,张萍,张萍,张萍,张萍,张萍.遗传性心律失常[J].医师进修杂志,2003,26(2):3-5. 被引量：1
-
7欧洲心脏病协会心性猝死专题组.关于心性猝死的专题报告(二)[J].现代实用医学,2002,14(11):623-625.
-
8于文敏.胺碘酮联合小剂量美托洛尔治疗室性心律失常的临床观察[J].中国社区医师,2009,25(2):22-22. 被引量：1
-
9李艺华.先天性长QT综合征并发尖端扭转型室速3例[J].实用心电学杂志,2000,9(6):435-436.
-
10戴爱国.分子生物学在呼吸系统疾病中的应用进展[J].临床内科杂志,1996,13(5):16-18.
