放射性核素胶体^(32)p在胸壁小切口胸腔镜治疗Ⅱ期肺癌中的应用(英文)

Radionuclide Colloid ^(32)P Used for the Treatment of Stage II Lung Cancer by Video Enhanced Minimal Access Muscle Sparing Thoracotomy

目的 探讨放射性核素胶体32p在胸壁小切口辅助电视胸腔镜肺叶切除治疗Ⅱ期肺癌中应用的可能性。方法 在双腔管气管插管常规全麻下实施电视胸腔镜手术。术中健侧肺单肺通气，第4或第5肋间8～10 cm切口，辅助胸腔镜下肺叶切除及清扫淋巴结，对手术中认为淋巴结清扫不彻底及淋巴结转移区域，局部注射放射性核素胶体32pMBq(5～10mCi)。结果 29例病人在VEMAST下完成肺叶切除，1例因肺动脉肿瘤包裹，术中出血改在常规开胸下完成肺叶切除，另1例因肺动脉无法与肿瘤分离而中转手术，无手术死亡，无严重并发症，无放射性核素胶体32p不良反应。结论 胸壁小切口辅助电视胸腔镜肺叶切除治疗Ⅱ期肺癌时，对手术中认为切除不满意或淋巴结转移处施行了放射性核素治疗。小切口辅助VATS下肺叶切除、使用放射性核素胶体32p有选择的治疗Ⅱ期肺癌是一种安全有效的治疗方法。

Objective: To study the feasibility of radionuclide colloid 32P used for the treatment of stage II lung cancer by video enhanced minimal access muscle sparing thoracotomy (VEMAST). Methods: Video assisted thoracoscopic surgery (VATS) was carried out under general anesthesia. A double lumen endobronchial tube was intubated into trachea. One lung ventilation of the healthy side was done during operation. An incision of 8–10 cm long was made along the 4th or 5th intercostals. The lobectomy could be performed under VATS. Radionuclide colloid 32P was injected locally into the area where surgical cleaning of lymph node around was considered to be unsatisfactory or desection of the tumor was not completed. Results: The operation with VEMAST was successful in 29 patients. A conventional lobectomy by thoracotomy had to be done due to unusual bleeding from the pulmonary artery involved during VEMAST in one case and the procedure was interrupted because the pulmonary artery cloud not be separated from the tumor in another patient. There was no dead case or the patient who had any severe complication or adverse response to the radiant. Conclusion: Radionuclide therapy was performed to the treatment of stage II lung cancer with VEMAST in case that surgical resection was considered not to be satisfactory. Minithoractomy assisted with VATS lobectomy and radionuclide colloid 32P therapy is a safe and e?ective technique for some selected stage II lung cancer.