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Preparation and Properties of Collagen-Chitosan/Glycosaminoglycans as Candidate Tissue Engineering Biomaterials 被引量:1

Preparation and Properties of Collagen-Chitosan/Glycosaminoglycans as Candidate Tissue Engineering Biomaterials
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摘要 A novel biomaterial scaffold was created from collagen chitosan/GAG. Its tensile strength was 8.6MPa(wet state)and degree of swelling water was 60%~75% with higer ultimate elongation 300%. Rabbit corneas of collagen chitosan/GAG implantation samples in vivo for biodegradation showed that the inplantion samples was complets biodegrable and digested afere 120 day. There was enought time to maintain cell growth,immigrating and proliferation. This biomaterials scaffold can be used for cell culture and in various tissue engineering fields. A novel biomaterial scaffold was created from collagen chitosan/GAG. Its tensile strength was 8.6MPa(wet state)and degree of swelling water was 60%~75% with higer ultimate elongation 300%. Rabbit corneas of collagen chitosan/GAG implantation samples in vivo for biodegradation showed that the inplantion samples was complets biodegrable and digested afere 120 day. There was enought time to maintain cell growth,immigrating and proliferation. This biomaterials scaffold can be used for cell culture and in various tissue engineering fields.
出处 《Chinese Journal of Biomedical Engineering(English Edition)》 2004年第2期47-51,共5页 中国生物医学工程学报(英文版)
关键词 COLLAGEN-CHITOSAN GAG Biomaterials scaffold Biodegradation in vivo 胶原质壳聚糖 氨基葡聚糖 组织工程材料 生物降解 GAG
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参考文献4

  • 1Itoh H,Aso Y,Furuse M,et al.A honeycomb collagen carrier for cell culture as a tissue engineering scaffold[].Artificial Organs.2001
  • 2Saika S. et al.Epithelial repair: Roles of Extracellular matrix[].Cornea.2002
  • 3Srivastava S,Gorham SD.In vivo evaluation and comparison of collagen, acetylated collagen and collagen glycosaminglycan composite films and sponges as candidate biomaterids[].Biomaterials.1990
  • 4Noishiki y.Dreams for the future in the field of in vivo tissue engineering[].Artificial Organs.2001

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