NO-1886对食饵性高糖高脂兔脂代谢的影响

Effect of NO-1886 on lipid metabolism in experimental rabbits with high-sugar and high-lipid caused by feeding

目的 观察NO - 1886对食饵性肥胖兔模型血糖、血脂和体质量的影响。方法 将新西兰兔随机分为 4组 ,每组 12只。A组喂普通饲料 ;B组先喂普通饲料 4周 ,然后在饲料中按 1.0 %的比例添加NO - 1886喂养 2 4周 ;C组喂高糖高脂饲料 (含 10 %的猪油、37%的蔗糖加普通饲料 ) ;D组先喂高糖高脂饲料 4周 ,然后在高糖高脂饲料中按1%的比例加NO - 1886喂养 2 4周。于实验 0 ,4 ,8,13,18,2 3,2 8周采血测血清HDL -C ,TG和FFAs及血清葡萄糖 ;实验期末 ,所有动物放血处死 ,分离腹部脂肪称质量。结果 喂养 2 8周后 ,D组血糖、TG和FFAs均明显低于C组 ,HDL -C明显高于C组 ,腹部脂肪明显少于C组 ,均有显著性差异 (P均 <0 .0 5 )。结论 NO - 1886具有降糖、降脂、减轻体质量的作用 ,可抑制腹部脂肪蓄积 ,预防肥胖。

Objective It is to observe the effects of NO-1886 on the blood sugar, blood lipid and body mass of experimental obese rabbit models.Methods The New Zealand rabbits were randomly divided into four groups in which there were twelve rabbits. Group A was fed with general fodder. Group B was fed with the general fodder for the primal four weeks and then NO-1886 in the proportion of 1.0% was added for the subsequent 24 weeks. Group C was fed with high-sugar and high-lipid fodder (contained 10% lard and 37% sucrose in the general fodder). Group D were fed with the high-sugar and high-lipid fodder for the primal four weeks and then NO-1886 in the proportion of 1% was added for the subsequent 24 weeks. The rabbits’ blood were gathered at the zero, 4th, 8th, 13th, 18th, 23rd, 28th week after treatment and the serum HDL-C, TG, FFAs and sugar were measured respectively. At the end of the experiment, all the rabbits were killed with bleeding and the abdominal fat was separated and weighed.Results Compared with group C after being fed for 28 weeks, the serum sugar, TG and FFAs in group D were obviously lower, the HDL-C in group D was obviously higher, and the abdominal fat was obviously lesser. All the differences were marked (P<0.05).Conclusion NO-1886 has the effect of reducing serum sugar, serum lipid and body mass. It can reduce the accumulation of abdominal fat and prevent adiposity.