摘要
Objectives: To report three cases of gonorrhea withspectinomycin treatment failure, and to analyze thepossible causes.Methods: Identification of the three Neisseriagonorrhoeae isolates was made by an oxidase test anda rapid carbohydrate utilization test. The sensitivitytesting was performed by an agar dilution method.Results: All three isolates were identified as Ngonorrhoeae strains by positive oxidase test andbecause they only utilized glucose in the carbohydrateutilization test. All three strains were resistant tociprofloxacin and susceptible to ceftriaxoneSpectinomycin-resistant strains were found in onlytwo of the three patients, including one penicillinase-producing N. gonorrhoeae (PPNG). The third patienthad a spectinomycin sensitive strain, which was alsoPPNG and tetracycline resistant (TRNG). Based onthe medical history, spectinomycin treatment failurefor the third patient was due to inadequate injection.Conclusion: The causes of spectinomycin treatmentfailure of gonorrhea include spectinomycin resistanceand inadequate injection.
目的首次报道3 例大观霉素治疗淋病失败病例,对其原因进行了研究分析。方法以氧化酶试验和糖发酵试验鉴定3 株淋球菌,用琼脂稀释法进行体外药物敏感性试验。结果 3 株菌均氧化酶阳性,糖发酵试验仅分解葡萄糖, 鉴定为淋球菌。药物敏感性试验3株淋球菌均对头孢曲松敏感,对环丙沙星耐药;2株淋球菌为耐大观霉素淋球菌,其中1株亦为产青霉素酶淋球菌(PPNG);第3株淋球菌为大观霉素敏感菌株,但为 PPNG 及耐四环素淋球菌(TRNG)。病史提示第3 例患者是因为药物注射不当或吸收剂量不足而至治疗失败。结论大观霉素治疗淋病失败的原因有耐药问题,还有注射不当。
