期刊文献+

12号染色体与阿尔茨海默病遗传易患性关联的研究进展 被引量:1

原文传递
导出
摘要 Alzheimer病的基因组扫描结果证实了12号染色体上AD疾病基因的存在。位于该染色体上的多个功能基因都被进行了研究,目前的研究热点集中在A2-巨球蛋白(A2M)基因、低密度脂蛋白受体相关蛋白(LRP)基因和转录因子LBP-1c/GP2/LSF基因上。
出处 《国外医学(神经病学.神经外科学分册)》 2004年第3期264-266,共3页 Foreign Medical Sciences(Section On Neurology & Neurosurgery)
  • 相关文献

参考文献18

  • 1Kostex MN, Dermaut B, Cruts M, et al. The alpha2 - macroglobulin gene in AD: a population - based study and meta - analysis.Neurology, 2000, 55(5): 678- 684.
  • 2Zappia M, CittadeUa R, Manna I, et al. Genetic association of alpha2- macroglobulin polymorphisms with AD in southern Italy. Neurology,2002, 59(5) : 756 - 758.
  • 3Mayeax R, Lee JH, Roams SN, et al. Chromosome- 12 mapping of late - onset Alzheimet disease among Caribbean Hispanics. Am J Hum Goner, 2002, 70(1): 237-243.
  • 4Romas SN,Mayeux R, Rabinowitz D, et al. The deletion polymorphism and Val1000Ⅱe in alpha - 2 - macroglobulin and Alzheimer disesse in Caribbean Hispanics. Neurosci Lett, 2000, 279(3) : 133 - 136.
  • 5Van Uden E, Kang DE, Koo EH, et al. LDL receptor- related protein(LRP) in Alzheimer' s disease: towards a unified theory of pathogeneais. Microsc Res Tech, 2000, 50(4): 268- 272.
  • 6Nathan BP, Jiang Y, Wong Gk, et al. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low - density lipoprotein rvceptor- related protein. Brain Res, 2002, 928(I-2): 96-I05.
  • 7Lambert JC, Chartier- Harlin MC, Cottle D, et al. Is the LDL receptor-related protein involved in Alzheimer' s disease? Neurogenetics,1999, 2(2): 109- 113.
  • 8HoUenbach E, Ackermann S, Hyman BT, et al. Confirmation of an association between a polymorphism in exon 3 of the low - density lipoprotein receptor- relaied protein gene and Alzheimer' s disease.Neurology, 1998, 50(6) : 1905 - 1907.
  • 9Hatanaka Y, Kamino K, Fukuo K, et al. Low density lipoprotein receptor- related protein gene polymorphisms and risk for late - onset Alzheimer's disease in a Japanese population. Clin C, enet, 2000, 58(4) : 319 - 323.
  • 10Sanchez - Guerra M, Combarros O, Irdante J, et al. Case - control study and meta- analysis of low density lipoprotein receptor - related protein gene exon 3 polymorphism in Alzheimer' s disease. Neumsci Lett, 2001, 316(1): 17-20.

同被引文献5

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部