超常规量阿托伐他汀对急性心肌梗死患者早期血管内皮功能的影响

Influence of over regular atrovastatin on early stage of vascular endothelial function in patients with acute myocardial infarction

目的 :探讨短期大剂量阿托伐他汀对急性心肌梗死 (AMI)患者血管内皮功能改善的早期疗效。方法 :将68例AMI患者分为大剂量组和常规量组 ,于AMI后24h内给予口服不同剂量的阿托伐他汀2周 ,分别测定治疗前后的血脂 (TC、TG、LDL -C、HDL -C)、反应性充血引起的肱动脉内径舒张率 (ΔD % )、血浆内皮素1(ET -1)、血浆组织型纤溶酶原激活物 (t-PA)以及血浆纤溶酶原激活物抑制物1(PAI -1)。结果 :大剂量组服药2周后血脂TC、TG、LDL -C下降 (P<0.05) ,(D %、t -PA明显增高 (P<0.01) ,ET -1、PAI -1明显减低 (P<0.01) ;常规量组上述指标均无变化。结论 :对AMI患者给予短期大剂量阿托伐他汀治疗在早期提高血管内皮功能方面明显优于常规剂量。

Objective: To investigate the previous effects of large dose atrovastatin in short time on vascular endothelial function in patients with acute myocardial infarction (AMI). Methods:68 patients with AMI were randomly divided into large dose group and regular dose group and took different dose atrovastatin for 2 weeks in 24 hour of AMI. Lipid(TC,TG,LDL-C,HDL-C),brachial artery relaxant rate of reaction to congestion((D%),plasma endothelin-1(ET-1),tissue type plasmiogen activator(t-PA) and plasmiogen activator inhibitor-1(PAI-1) were measured before and after treatment of atrovastatin.Results: After 2 weeks of taking atrovastatin in large dose group, lipid(TC,TG,LDL-C) level was decreased(P<0.05). (D%, t-PA were markedly increased(P<0.01). ET-1, PAI-1 were markedly decreased(P<0.01).But there were not changed of above parameters in regular dose group . Conclusion: Effects of large dose atrovastatin treatment on AMI patients in short time for increasing previous vascular endothelial function is better than that of regular dose.