摘要
为了简化头孢地嗪钠的合成路线,以乙酰丙酸为起始原料,经氯化、环合、酸析、缩合、成盐等反应,制备头孢地嗪钠,该合成路线工艺简单,反应条件要求低,适合工业化生产。
In order to predigest the A preparation of cefodizime sodium,staring from 4-oxo- pentanoic acid via chlorization,cyclization,acid neutralization,condensation and silification.The course reactions were carried out under moderation and more suitable for industrial process.
出处
《黑龙江医药》
CAS
2004年第4期263-264,共2页
Heilongjiang Medicine journal
