葡萄柚汁对辛伐他汀药代动力学的影响

The affection on the pharmacokinetic of Simvnstatin by grape extract

辛伐他汀是降血脂的常用药物,与葡萄柚汁合用可大大增加其酸的血清浓度。试验表明合用后辛伐他汀的平均 C_(max)增加了9.4倍.而辛伐他汀酸的平均 C_(max)和 AUC_(0—∞)升高约7倍。这些在临床用药时应予以注意。

Simvastatin(SV)is a kind of drug used usually to hyperlipemia.The concentration of SV and its acid in plasma is markedly increased when used grape extract at the same time.It in-dicates that it is 9.4 times the normal concentration of SV average C_(max)while it is about 7-timesthe normal concentration of SV acid average C_(max) and AUC_(0-∞)in the test.All the matters need at-tention when clinical application.