摘要
在酸性条件下,沙丁胺醇(1)可与高锰酸钾产生化学发光,因此建立了流动注射化学发光法测定1片和气雾剂的含量。方法检测限为60ng/ml,1在0.2～80mg/ml浓度范围内与化学发光强度呈良好的线性关系(r>0.99),方法精密度为1.4%,所得结果与药典方法测得值一致。
A chemiluminescence method for determination of salbutamol tablets and aerosol by flow injectiontechnique was established. It was based on the chemiluminescence reaction of KMnO4-salbutamol in acidic medium. Thedetection limit was 60ng/ml. The calibration curves were linear in the concentration range of 0.2～80mg/ml(r>0.99). TheRSD was 1.4%. The results showed that the method was comparable with the Ch.P. method.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第7期425-426,共2页
Chinese Journal of Pharmaceuticals
关键词
沙丁胺醇
气雾剂
化学发光
流动注射
测定
salbutamol
aerosol
chemiluminescence
flow injection
determination
