广州地区淋球菌对环丙沙星的耐药性监测

Surveillance of Resistance of Neisseria Gonorrhoeae to Ciprofloxacin

目的 :监测广州地区 2 0 0 0年 -2 0 0 3年分离的淋球菌对环丙沙星的耐药性 ,为制定淋病防治策略和修改淋病的治疗方案提供参考依据。方法 :采用琼脂稀释法测定菌株对环丙沙星的最小抑菌浓度 (MIC) ,计算耐药百分率、MIC50 、MIC90 和MIC均 。结果 :从 2 0 0 0年 -2 0 0 3年共检测 3 96株淋球菌 ,耐药菌 3 44株 ,占 86 7%。淋球菌对环丙沙星耐药率由 2 0 0 1年的 73 7%上升到 2 0 0 3年的 93 6% ,呈稳步上升趋势。环丙沙星的MIC50 、MIC90 和MIC均 4年间增加了 1倍。结论 :广州地区淋球菌对环丙沙星耐药率很高 ,且呈稳步上升趋势 ,环丙沙星不再适宜被推荐用于对淋病治疗的首选药物。

Objective:To investigate the susceptibility of Neisseria gonorrhoeae to ciprofloxacin in Guangzhou 2000-2003, to provide evidence for formulation of treatment guideline and making control policy. Methods: Agar dilution method was used to detect antibiotic susceptibility and the method of probability is used for calculation of MIC 50 、 MIC 90 and MIC mean . Results: A total of 396 gonococcal strains were tested from 2000 to 2003, The resistant strains for ciprofloxacin were 344(86.7%). The resistant rate was increased to a higher level, from 73.7% in 2001 to 93.6% in 2003. MIC 50 、 MIC 90 and MIC mean of ciprofloxacin increased one fold respectively during the four years. Conclusion: The neisseria gonorrheae in guangzhou showed a high resistance to ciprofloxacin, and the study indicated that the tendency of ciprofloxacin resistance in gonococci isolated was continuously growing. Ciprofloxacin should not be used as the first-line agent in the treatment of gonrrhoea.