骨保护素与冠心病关系的探讨

Study on relationship between serum level of osteoprotegerin and coronary heart disease

目的 探讨血清骨保护素 (osteoprotegerin ,OPG)水平与冠心病的关系。方法 90例住院患者 ,根据冠状动脉造影的结果分为冠心病组 6 4例及对照组 2 6例 ,采用ELISA法测定OPG水平与吸烟史、糖尿病、高血压、年龄、性别、体重指数、血钙、血脂各指标之间的关系。结果 冠心病组患者血清中OPG水平明显高于对照组 ,P <0 0 5。OPG水平随冠状动脉病变支数的增加而升高 (P <0 0 0 1)。冠状动脉造影正常或内腔轻度不规则、单支病变、2支病变、3支病变的患者 ,其血清中OPG水平分别为 ( 0 10 4± 0 0 35 ) ,( 0 111± 0 0 37) ,( 0 130± 0 0 84 ) ,( 0 16 9± 0 0 77) μg/L。 结论OPG水平升高与冠心病密切相关 ,OPG浓度越高 ,冠状动脉病变越严重。

Objective To study the relationship of serum osteoprotegerin and coronary heart disease(CHD). Methods According angiography,sixty four CHD patients were enrolled as CHD group and twenty six non CHD patients as control group, CHD group was divided into single ,double ,triple vessel groups.The serum level of osteoprotegerin was measured by ELISA in all subjects who had received coronary angiography (CAG).The relations between OPG and cigarette smoking,diabetes,hypertension,age, sex, body mass index, Ca 2+ ,blood lipid were analyzed. Results The level of serum OPG was significantly higher in patients with CHD than in the control group (0 1376±0 0614 μg/L vs 0 1042±0 0354 μg/L, P <0 05). As the stenosis vessels increased, the OPG levels also increased ( P <0 001).The serum OPG levels of no stenosis, single ,double , triple vessel group were 0 104±0 035 μg/L,0 111±0 037 μg/L, 0 13±0 084 μg/L,0 169±0 077 μg/L respectively. Conclusion OPG may be directly related to the initiation and development of coronary lesions. The higher level of serum osteoprotegerin, the greater the degress of coronary arteries lesions would be.