腔隙性脑梗死认知功能障碍的相关危险因素研究

Relative risk factors of lacunar infarct cognitive impairment

目的:探讨腔隙性脑梗死性认知功能障碍(lacunarinfarctcognitiveim-pairment,LICI)的相关危险因素。方法:选择98例住院诊断为腔隙性脑梗死性患者作为研究对象,除评定一般自然状况外,采用Hachinski缺血指数量表(Hachinskiischemicscale,HIS)、简易智力状态检查量表(mini-mentalstateexamination,MMSE)、汉密顿抑郁量表(Hamiltondepressionscale,HAMD)、改良爱丁堡斯堪的那维亚神经功能缺损评分量表、伴发疾病评分量表对入组患者进行评定,对所有患者进行颅脑CT扫描,神经元特异性烯醇化酶(neuroalspecificityenolase,NSE)检测。结果:LICI的发生率为38%(37/98)。单因素分析显示LICI的发病主要反映在病灶体积(t=2.792,P=0.007)与NSE值(t=3.062,P=0.003)。LICI组与非LICI组的多元Logistic逐步回归(后退法)分析显示LICI的发病主要与高血压、脑卒中次数、病灶最前点与额极的距离、病灶体积相关。结论:LICI的发生率较高,LICI的发病是多因素作用的结果。

AIM:To study the relative risk factors of lacunar infarct cognitive impairment(LICI). METHODS:Ninety eight inpatients with lacunar infarct were evaluated their natural status as well as other indexes by Hachinski ischemic scale(HIS),mini mental state examination(MMSE),Hamilton depression scale(HAMD),neurologic deficit scale,and complication scale.All the patients received brain CT scan and neuro specific enolase(NSE) test. RESULTS:The incidence rate of LICI was 37.8%(37/98).One factor analysis indicated that the onsets of LICI were reflected by the volume of lesions(t= 2.792,P=0.007)and NSE values(t=3.062,P=0.003).Multiple logistic stepwise regression analysis(backward method) showed that the onset of LICI had correlation with hypertension, times of infarct stroke,the distance between the focal frontest point and frontal pole,and volume of lesions. CONCLUSION:The onset rate of LICI is comparatively high.It is related to multiple factors.