军人创伤后应激障碍患者脑诱发电位的3种变异

Three variations of brain evoked potentials of army men with post-traumatic stress disorder

目的:探讨军人创伤后应激障碍(post-traumaticstressdisorder,PTSD)患者3种脑诱发电位(brainevokedpotential,BEP)的变异。方法:应用美国NicoletBravo型脑诱发电位仪,采用光、声刺激和Click短声刺激,检测75例PTSD患者(研究组)和46名健康军人(对照组)的视觉诱发电位(visualevokedpotential,VEP)、听觉诱发电位(auditoryevokedpotential,AEP)和脑干听觉反应(auditorybrainstemresponse,ABR)。结果:①VEP:Cz脑区的P2波幅研究组低于对照组犤(4.4±4.1)和(9.0±5.2)μV,t=5.40,P<0.01犦,Pz脑区的P3波幅研究组低于对照组犤(5.1±4.0)和(8.1±4.5)μV,t=3.82,P<0.01犦。②AEP:Oz脑区的P3潜伏期研究组长于对照组犤(330.2±30.7)和(298.1±27.4)ms,t=5.81,P<0.01犦,Cz脑区的P2波幅研究组低于对照组犤(2.8±1.7)和(4.5±1.8)μV,t=5.22,P<0.01犦,Cz脑区的P3波幅研究组高于对照组犤(4.2±2.1)和(2.2±1.0)μV,t=6.05,P<0.01犦。③ABR:Pz脑区的波Ⅴ绝对潜伏期研究组长于对照组犤(5.8±0.3)和(5.4±0.2)ms,t=8.01,P<0.01犦,Oz脑区的波Ⅴ绝对潜伏期研究组短于对照组犤(6.4±0.3)和(6.9±0.3)ms,t=8.90,P<0.01犦。Pz脑区的波Ⅳ绝对波幅研究组低于对照组犤(0.24±0.12)和(0.40±0.10)μV,t=7.57,P<0.01犦。

AIM:To investigate three variations of brain evoked potentials(BEP) in army men with post traumatic stress disorder(PTSD). METHODS:Seventy five patients with PTSD(research group) and 46 healthy army men(control group) were detected including their visual evoked potential(VEP),auditory evoked potential(AEP),and auditory brainstem response(ABR), with Nicolet Bravo Instrument and light,sound and Click stimulation. RESULTS:①VEP:The amplitude P2 of Cz in the research group was lower than that of the control group[(4.4 ±4.1) and(9.0±5.2) μV,t=5.40,P< 0.01],and so was the amplitude P3 of Pz[(5.1±4.0) and(8.1±4.5) μV,t=3.82,P < 0.01].②AEP:The latency of P3 of Oz in research group was longer than that of the control group[(330.2±30.7) and(298.1±27.4) ms,t=5.81,P < 0.01],while amplitudes P2 of Cz in research group was lower than that of the control group[(2.8±1.7),(4.5±1.8) μV and t=5.22,P < 0.01] and amplitudes P3 of Cz in the research group was higher than that of the control group[(4.2±2.1) and(2.2±1.0)μV,t=6.05,P< 0.01].③ABR:Compared with the control group, research group showed prolonged latency of wave Ⅴfrom Pz[(5.8±0.3) and(5.4±0.2) ms,t=8.01,P< 0.01],absdute shortened latency of wave Ⅴfrom Oz[(6.4±0.3) and(6.9±0.3) ms,t=8.90,P< 0.01],and decreased the amplitudes of wave Ⅳfrom Pz [(0.24±0.12) and(0.40±0.10) μV,t=7.57,P < 0.01] and wave Ⅱfrom Oz[(0.38±0.11) and(0.51±0.12) μV,t=6.10,P< 0.01]. CONCLUSION:The variation characteristics of BEP can serve as a physiological index in assisting diagnosis of PTSD.