摘要
目的:采用Feeney法自由落体撞击脑损伤动物模型,观察纳洛酮对脑损伤大鼠脑组织氧代谢的影响。方法:40只大鼠分为实验组及对照组,在损伤后分别给予纳洛酮或生理盐水,采用Neurotrend系统观察脑组织氧分压、脑组织二氧化碳分压、脑组织pH值和HC03-的变化。结果:与对照组比较,大鼠脑损伤后,纳洛酮治疗组脑组织氧分压犤(2.75±0.95)kPa比(5.12±0.65)kPa犦显著升高(t=2.98959,P<0.01)、脑组织二氧化碳分压犤(9.32±0.98)kPa比(7.03±1.62)kPa犦显著降低(t=2.46274,P<0.01)、脑组织pH值显著升高(P<0.05)。结论:研究结果提示纳洛酮作为阿片受体的拮抗剂有显著改善脑组织氧代谢的作用。
AIM:To investigate the effect of naloxone on cerebral oxygen metabolism in rats with brain injury caused by free fall with Feeney's method. METHODS:A total of 40 SD rats were divided into experimental group and control group. Naloxone or saline was injected into rats of the two groups respectively after the injury.The changes of brain tissue partial oxygen pressure(PbtO2),carbon dioxide pressure(PbtCO2),pH(pHbt),and HCO3-were continuously monitored by Neurotrend system. RESULTS:Compared with the control group,the PbtO2[(5.12±0.65) kPa vs(2.75±0.95) kPa] in naloxone treatment group increased obviously(t=2.989 59,P< 0.01),while the PbtCO2[(7.03±1.62) kPa vs (9.32±0.98)kPa] decreased obviously(t=2.462 74,P< 0.01 and the pHbt rised significantly after brain injury(P< 0.05). CONCLUSION:Naloxone, as an opium receptor antagonist,can improve cerebral oxygen metabolism significantly.
出处
《中国临床康复》
CSCD
2004年第19期3804-3805,共2页
Chinese Journal of Clinical Rehabilitation
