异体周围神经移植研究进展

ADVANCES IN PERIPHERAL NERVE ALLOGRAFT

目的 介绍近期国内外有关异体周围神经移植的研究进展。 方法 广泛查阅近期相关文献 ,综合分析对移植神经和受体的处理方法。 结果 应用物理、化学及生物学方法均可降低移植神经的免疫原性 ;给予受体免疫抑制治疗也可减轻免疫排斥反应 ,促进神经再生。 结论 目前异体神经移植的效果不及自体神经移植理想 ,成功诱导受体对移植神经产生终身免疫耐受 ,可望解决这一问题。

Objective To investigate the research advances of the peripheral nerve allograft. Methods The recent articles on peripheral nerve allograft were reviewed extensively. The treatments of allograft and host were analyzed. Results The immunogenicity of allograft was relieved by the physical, chemical or biological treatments; the immunosuppressive therapy makes the rejection relieved and the regeneration of axon accelerated. Conclusion The effect of peripheral nerve allograft is inferior to autograft. If the immunologic tolerance are induced successfully, the problem shall be solved.