丝裂霉素C在高频电泪道成形术中的应用

Application of mitomycin C in high frequency electrolacryocystoplasty

目的 评价丝裂霉素 C(mitomycin C,MMC)在高频电泪道成形术中的作用。方法 将 6 2例 (73只眼 )慢性泪囊炎患者随机分成 2组 ,MMC组 32例 (38只眼 )于高频电泪道成形术后应用 0 .4 m g/ m l MMC 10分钟后 ,术毕应用典必舒眼膏充填泪道 ;对照组 30例 (35只眼 )常规高频电泪道成形术 ,应用典必舒眼膏充填泪道与MMC组相同 ,术后随访 12～ 18月 ,观察泪道通畅情况等指标。结果 MMC组手术成功率为 89.5 % ,显著高于对照组 6 5 .7% (P <0 .0 5 )。结论 0 .4 mg/ ml MMC可有效减少高频电泪道成形术后泪道疤痕的形成 。

Objective To evaluate the effects of mitomycin C (MMC) in high frequency electrolacryocystoplasty.Methods Sixty-two patients(73 eyes)with chronic dacryocystitis were randomly divided into MMC group and control group. In MMC group,32 cases (38 eyes )firstly applied 0.4mg/ml MMC 10 minutes and then filled up TobraDex ointment.In control group,30 cases ( 35 eyes) didn't apply MMC. All patients were followed up for 12～18 months.Results The success rate of operation was 89.5% in MMC group and 65.7% in control group(P<0.05).Conclusion MMC(0.4mg/ml) can effectively inhibit the scar formation, thus providing a higher successful in high frequency electrolacryocystoplasty.