复合离子盐对自发性高血压大鼠胰岛素抵抗相关因素的影响

Effects of Compound Ion Salt on the Relative Factors of Insulin Resistance in Spontaneous Hypertensive Rats

目的 :本研究通过观察不同剂量复合离子盐对自发性高血压大鼠 (SHR)胰岛素抵抗相关因素的影响 ,探讨复合离子盐能否对原发性高血压起到防治作用。方法 :对61只自发性高血压大鼠分别饲以复合离子盐 (高、低盐实验组 )及普通加碘盐 (高、低盐对照组 ) ,动态观测动物血压变化 ,检测大鼠血糖、血胰岛素水平,计算胰岛素敏感指数。结果 :(1)复合离子盐较普通加碘盐具有明显的预防高血压作用 ,高盐实验组血压明显低于高盐对照组(P<0.01)。 (2)4组血糖水平差别无统计学意义 (P>0.05) ;高盐对照组胰岛素水平高于其他3组 (P<0.05) ,胰岛素敏感指数明显低于其他3组 (P<0.05)。高盐实验组血糖和胰岛素水平与低盐实验组差别无统计学意义 (P>0.05)。结论 :复合离子盐对SHR的高血压有防治作用 。

Objective:To observe the effects of different doses of compound ion salt on the relation faetors of insulin resistance in spontaneous hypertensive rats,and to investigate the preventive effects on primery hyperˉtension rats.Methods:The rats were treated with compound ion salt and common salt in different levels.Durˉing the period,the blood pressure was measured every week.After8weeks,the rats were sacrificed,and blood glucose and plasma insulin levels were measured.Results:(1)The compound ion salt had an apparent anti-hypertensive effect.The blood pressure in high salt case group was lower than that in high salt control group(P<0.01).(2)The blood glucose levels in the four groups had no difference(P>0.05).The plasma insulin level in the high salt control group was higher than others(P<0.05).The insulin sensitive index in high salt control group was lower than others(P<0.05).There was no significant difference in blood glucose and insulin levels between high and low salt case groups(P>0.05).Conclusion:The compound ion salt had an anti_hypertensive effect,and it did not increase insulin resistance of SHR.