吸烟与阿尔茨海默病

Smoking and Alzheimer Disease

目的 探讨吸烟与阿尔茨海默病 (AD)的关系。方法 以社区为基础进行 1∶ 1配对病例对照研究。结果 共 2 82对患者和对照者纳入研究 ,与≥ 5 0岁以后不吸卷烟者相比 ,5 0岁以后吸烟量为 0 .1～ 9.9包年者的 OR值为 0 .748(95 % CI :0 .5 3 6～ 1 .0 45 ) ,吸烟量≥ 1 0包年者的 OR值为 0 .5 60 (95 % CI:0 .2 87～ 1 .0 91 ,P =0 .0 884)。被动吸烟与 AD无显著性联系 (P =0 .95 68)。结论 ≥ 5 0岁时吸卷烟可能对 AD有保护作用 ,且两者间的联系有边缘统计学意义 ,因此值得扩大样本量或选取暴露率更高的目标人群进一步研究。

Objective To evaluate the association between cigarette smoking and Alzheimer disease (AD). Methods An age, sex, educational level, 1∶1 matched case control study was conducted in Beijing, Shanghai, Chengdu, and Xi'an. Cases and controls were drawn from a prevalence study of dementia in elderly population in these cities. The risk of AD related to smoking was fitted to univariate and multivariate conditional Logistic model. Results Two hundred and eighty-two AD patients and 282 non-demented controls were recruited for the study. The mean incidence age of cases was(76.0±8.2)years old. The dose of smoking was quantitated by pack-year that is pack of cigarette smoking per day multiply year of smoking. The ORs was adjusted by marriage status, economic status, occupation, living status, and family history of first-degree relatives. With never-smokers as the reference category, we observed reduced risk for ADamongsmokerswhose dose were between 0.1 to 9.9 pack-years ( OR = 0.748, 95% CI :0.536-1.045 ), and smokerswhosedosewere10 pack-years or more ( OR =0.560, 95% CI :0.287-1.091, P =0.0884) when they were 50 years old or more. Objective smoking has no connection with AD ( P =0.9568). Conclusions The study demonstrated that cigarette smoking might have some protective effects to AD, but the connection only reached marginal significance level. Further study should be conducted to convince this connection.