砂仁挥发油中乙酸龙脑酯镇痛抗炎作用的研究

Studies on the Analgesic and Anti-inflammatory Effect of Bornyl Acetate in Volatile Oil from Amomum villosum

目的 :研究砂仁挥发油主要成分乙酸龙脑酯的镇痛抗炎作用。方法 :小鼠热板致痛实验 ,冰醋酸致小鼠疼痛实验 ,二甲苯致小鼠耳廓肿胀实验。结果 :乙酸龙脑酯高剂量组对小鼠热板致痛的痛阈值有一定程度的提高 ;对小鼠醋酸致痛引起的扭体次数有明显的降低作用 ;能抑制二甲苯致小鼠耳廓肿胀炎症。结论

Objective:To study analgesic and anti-inflammatory effects of bornyl acetate,the main ingredient of Amomum villosum volatile oil.Methods:The analgesic effects were tested by hot-plate and writhing reaction method,the ear swelling caused by dimethylbenzene in mice. Results:Bornyl acetate could restrain writhing reaction caused by acetic acid glacial,lighten the pain caused by hot-plate. It could also suppress ear swelling caused by dimethylbenzene in mice.Conclusion:Bornyl acetate shows analgesic and anti-inflammatory effects.