钙黏蛋白-链蛋白复合体在进展期胃癌转移淋巴结的再表达及其临床意义

Re-expression of cadherin-catenin complex in metastatic lymph nodes from advanced gastric cancer and clinical significance

目的 探讨钙黏蛋白 链蛋白 (Cadherin catenin)复合体在进展期胃癌转移淋巴结的再表达及其临床意义。方法 用免疫组织化学染色的方法检测并比较上皮钙黏蛋白 (E cadherin) ,α 和 β 链蛋白 (catenin)在 96例胃癌原发灶与 79例转移淋巴结内的表达 ,并结合临床病理资料与随访结果进行综合分析。结果 79例转移淋巴结中 5 2例 (66%)出现了一个或多个蛋白分子的再表达 ,并与肿瘤的临床病理分期密切相关 ;再表达阳性组和阴性组的 5年生存率分别是 8%和 3 3 %,两者差异有显著性 (P <0 .0 1)。结论 钙黏蛋白 链蛋白复合体在进展期胃癌转移淋巴结的再表达对癌细胞在转移灶的聚集生长起着重要作用 ,可作为胃癌预后的一个新指标。

Objective To investigate the re-expression of cadherin-catenin complex in metastatic lymph nodes from advanced gastric cancer,and to evaluate its clinical significance.Methods Immunohistochemical expression of E-cadherin,α- and β-catenin was detected in 96 cases of primary advanced gastric cancers and 79 cases of metastatic lymph nodes.The expression levels of these adhesion molecules were compared between primary tumors and metastatic lymph nodes,and whose correlation with clinicopathological characteristics and survival time of patients were analyzed.Results In 79 cases of metastatic lymph nodes,re-expression of one or more adhesion molecules was detected in 52 cases (66%),and in the more advanced stage.The overall 5-year survival rate in the group of positive re-expression (8%) was significantly lower than that in the group of negative re-expression (33%,P <0.01).Conclusion The re-expression of cadherin-catenin complex in metastatic lymph nodes from advanced gastric cancer correlates with tumor stage and may play an important role in the re-growth of cancer cells in metastatic foci.The re-expression levels in metastatic loci may provide new prognostic information for patients with advanced gastric cancer.