C-12多肿瘤标志物检测对良恶性腹水鉴别诊断价值的探讨

Value of C-12 Tumor Markers Detection in the Differential Diagnosis of Malignant and Non-malignant Ascites

目的 探讨鉴别良恶性腹水的新方法。方法 比较两组患者 12 6例血清C -12肿瘤标志物的检测情况。结果恶性腹水组血清CEA、AFP、CA19-9及CA2 42水平较良性腹水组升高 (P <0 0 1) ,其诊断恶性腹水的敏感性分别为 73 6%,76 4%,87 5 %,3 6 1%,特异性分别为 88 9%,81 5 %,79 6%及 98 1%。C -12结果中 3项以上阳性对恶性腹水的敏感性为 62 5 %,特异性达 96 3 %。结论 肿瘤标志物检测有助于良恶性腹水的鉴别诊断 ,C -12可同时检测 12种肿瘤标志物 。

Objective To explore the new method for the differential diagnosis of malignant and non-malignant ascites. Methods 126 patients with ascites including 39 cases of liver cirrhosis,15 cases of tuberculous peritonitis,33 cases of hepatocellular carcinoma and 39 cases of other malignant tumors were enrolled in this study.The levels of serum C-12 tumor markers were measured. Results The levels of serum CEA, AFP, CA19-9 and CA242 were remarkably higher in malignant ascites than thos in non-malignant ascites(P<0 01). The diagnostic sensitivity of CEA, AFP, CA19-9 and CA242 in the malignant ascites were 73 6%,76 4%,87 5% and 36 1%,respectively, and the specificity of those were 88 9%,81 5%,79 6% and 98 1% respectively. The diagnostic sensitivity of C-12 with more than 3 positive markers in the malignant ascites were 62 5%, and the specificity of that were 96 3%. Conclusion The results suggested that tumor markers detection was helpful to the differential diagnosis of malignant and non-malignant ascites. The combination assay of 12 kinds of tumor markers by C-12 protein chip could increase the diagnostic sensitivity and specificity of malignant ascites.