奥丹西隆对小鼠吗啡条件性位置偏爱效应的影响

EFFECT OF ONDANSETRON ON MORPHINE-INDUCED PLACE PREFERENCE IN MICE

目的 :探讨 5 -HT3 型受体特异性拮抗剂奥丹西隆对吗啡诱导的条件性位置偏爱 (CPP)效应的影响。方法 :建立小鼠吗啡CPP模型 ,观察奥丹西隆对CPP的影响。结果 :吗啡 (5mg·kg-1,sc)可诱导小鼠对伴药箱产生显著的CPP ;测试前 30min注射奥丹西隆 (0 0 1- 1mg·kg-1,sc)不影响小鼠已形成的对吗啡的位置偏爱 ;而训练阶段于每次注射吗啡同时注射奥丹西隆 (0 0 1- 0 1mg·kg-1,ip)可拮抗小鼠对吗啡的CPP效应 ,但较大剂量奥丹西隆 (1mg·kg-1,ip)则不影响其效应 ,而且此剂量单独给药亦表现出自身的CPP潜力。结论 :一定剂量的奥丹西隆可拮抗小鼠对吗啡的偏爱效应的获得 ,但不影响其表达 ,提示该类药物有治疗阿片类依赖的潜力。

Objective: To study the effect of ondansetron(OND),a 5-HT 3 receptor antagonist, on morphine-induced conditioned place preference(CPP) in mice. Methods: Established a morphine CPP model in mice and observed the effect of OND on the model. Results: 5 mg·kg-1 morphine (MOR, sc) induced mice to obtain a significant place preference. When mice were pretreated with OND 0.01-1 mg·kg-1(sc) only once 30 min before the testing phase, the CPP induced by MOR was not affected. In contrast, OND 0.01-0.1 mg·kg-1 was administered(ip) at each injection of MOR during the conditioning phase, the place preference induced by MOR was antagonized remarkably, however, with higher dose(1 mg·kg-1,ip),the antagonist effect became variable, and OND given alone seemed also having CPP producing potential in mice at this dose. Conclusion: At certain doses, OND may antagonize the acquisition, but not the expression of MOR-induced CPP, which suggests that OND might be useful in the treatment of opiate dependence.