摘要
目的 :评价盐酸羟考酮的精神依赖性潜力。方法 :大鼠静脉自身给药法。结果 :与生理盐水自身对照相比 ,盐酸羟考酮在点燃剂量 0 5mg·kg-1和梯度剂量 0 2 5mg·kg-1下 ,触鼻次数显著增加 ,P <0 0 0 1,均形成稳定的自身给药行为 ;而两种不同剂量下盐酸羟考酮的日摄入总量 (totaldailydose ,TDD)无显著性差异。结论 :盐酸羟考酮具有较强的精神依赖性潜力。
Objective: To assess the psychic dependence potential of oxycodone hydrochloride. Methods: The technique of intravenous self-administration by rats was utilized. Under fixed-ratio=1 schedule of drug injection, one nose-poke response result in drug delivery to the rat. Results: All the rats trained with oxycodone at dose 0.5 mg·kg-1 showed self-administration behavior. The number of nose-poke response to oxycodone was much more than that to saline (P<0.001). As the dose of oxycodone hydrochloride lowered to 0.25 mg·kg-1, the number of nose-poke response to oxycodone increased significantly (P<0.001), while the total daily dose (TDD) of oxycodone hydrochloride infusions changed insignificantly (P>0.05). Conclusion: Oxycodone hydrochloride has psychological dependence potential.
出处
《中国药物依赖性杂志》
CAS
CSCD
2004年第2期109-111,共3页
Chinese Journal of Drug Dependence
