氯氮平与传统抗精神病药对精神病人糖尿病发病率的临床调查

The clinical survey of incident rate of diabetes caused by clozapine and classical antipsychotic drugs

目的:探讨氯氮平与传统抗精神病药(氯丙嗪、氟哌啶醇)对糖尿病发病率的影响。方法:回顾性调查应用氯氮平或氯丙嗪、氟 哌啶醇治疗的住院病人,收集血糖变化的数据。结果:在被调查的126例住院病人中,氯氮平组74例,糖尿病发生率为12%;氯丙嗪和氟哌啶 醇组52例,糖尿病发生率为0%。氯氮平与氯丙嗪及氟哌啶醇相比引起糖尿病有显著差异(P<0.05)。结论:氯氮平比传统抗精神病药易引 起糖尿病。

Objective:To explore the incident rate of diabetes caused by clozapine and classical anti-psychotic drugs(chlorˉpromazine and haloperidol).Methods:126in-patients with psychosis took clozapine,chlorpromazine or haloperidol were retrospecˉtively studied.The data of the reports about the concentration of glucose in the blood were collected.Results:In126cases,the clozˉapine group had74cases and the incident rate of diabetes mellitus was12%,the classical anti-psychotic drugs group had52cases and the incident rate of diabetes mellitus was0%.The incident rates of diabetes mellitus between the two groups were statistically significant difference(P<0.05).Conclusions:The risk of diabetes mellitus caused by clozapine is higher than classical anti-psyˉchotic drugs.