全肠外营养对早产儿营养、免疫功能及行为发育的影响

Effect of total parenteral nutrition on nutritional status, immunity and behavior of premature infants

【目的】 探讨全肠外营养 (TPN )对早产儿营养、免疫功能及行为发育的影响。 【方法】 监测 5 5例TPN治疗早产儿的营养状况、肝肾功能、血脂水平、免疫功能及矫正胎龄 40周时行为发育情况 ,并与 2 5例未行TPN的早产儿对照分析。 【结果】 TPN治疗组体重增长快、体重日增长及治疗后体重高于对照组 ,TPN治疗后血清蛋白、免疫球蛋白及补体水平升高 ,肝肾功能及血脂检查无明显异常 ,矫正胎龄 40周时NBNA评分高于对照组。 【结论】 TPN能改善早产儿营养状况、促进免疫水平的提高和行为神经的发育 ,对早产儿的治疗有重要意义。

To study the effect of total parenteral nutrition (TPN) on nutritional status,immunity and behavior of premature infants. 55 premature infants treated with TPN were studied as TPN group. The nutritional status, hepatic function, renal function, blood lipid, immunity and Neonatal Behavioral Neurological Assessment (NBNA) at remedied 40 weeks of gestational age were examined, compared with 25 non TPN treated premature infants as control group. The body weight gain velocity, daily body weight gain and body weight after TPN of TPN group were higher than control group. The serum protein, immunoglobulin and complements level of TPN group increased markedly after TPN, the hepatic function, renal function and blood lipid had no notable abnormalities. The NBNA scores of TPN group at remedied 40 weeks of gestational age were higher than control group. [Conclusion] TPN may improve the premature infants nutrition, promote the immunity and behavior development. It’s an effective therapy to premature infants.