川芎嗪对妊高征患者血中SOD、MDA、NO、ET、TXA_2、PGI_2及母儿结局的影响

Effect of Salvia Injection, Ligustrazine Treatment and Magnesium Sulfate Treatment on Plasma SOD,MDA,NO,ET,TXA_2 and PGI_2 and Pregnant Outcome in Patients with PIH

目的探讨川芎嗪对妊高征患者血中SOD、MDA、NO、ET、TXA2、PGI2及母儿结局的影响。方法川芎嗪治疗中度妊高征患者各75例,观察患者的SOD、MDA、NO、ET、TXA2、PGI2、平均动脉压、尿蛋白、眼底动脉的变化情况。结果治疗后患者SOD、NO、PGI2、ET、MDA、TXA2较前比较均有显著改善(P<0.05);治疗前后平均动脉压变化无显著差异(P>0.05);尿蛋白较治疗前有明显改善(P<0.05)。结论川芎嗪治疗妊高征时能改善母血中SOD、MDA、NO、ET、TXA2、PGI2。

Objective To determine the effect of salvia injection(SI), ligustrazine treatment and magnesium sulfate treatment on plasma concentrations of SOD,MDA,NO,ET,TXA2, PGI2, and pregnancy outcomes in women with pregnancy induced hypertension(PIH).Methods 75 women with mild PIH were randomly divided into SI treated group(75 cases),ligustrazine treated group(75 cases) and magnesium sulfate treated group(75 cases).The levels of serum SOD, MDA, NO, ET,TXA2, PGI2 and blood pressure were measured. Postpartum hemorrhage, fetal distress, and neonatal asphyxia were monitored. Results There were significant difference in the levels of serum SOD, MDA, NO, ET,TXA2, and PGI2 before treatment and after treatment in three groups(P< 0 05). On the other hand, the magnesium sulfate treated group had higher incidences of fetal distress than that of the other two groups(P< 0 05), while there was no difference in blood pressure drop and the incidence of neonatal asphyxia in all groups(P >0 05). Conclusion Our study shows that all the three treatments can maintain the levels of SOD, MDA, NO, ET,TXA2, and PGI2 in women with PIH. However, magnesium sulfate treatment can lead to fetal distress.