吡喹酮治疗脑囊虫病患者血清中Th1/Th2细胞因子的变化及临床意义(英文)

Regulation of Th1 and Th2 Type Cytokines in the NCC Patients Treated with Praziquantel

目的探讨脑囊虫病患者经吡喹酮治疗后,机体免疫应答的状态和对病程转归影响。方法35例脑囊虫病患者经吡喹酮治疗6个月后,对血清中IL-2、INF-γ、IL-5、IL-10、TNF-α、IL-12进行检测。结果治疗6个月后,Th1型细胞因子IL-2、IFN-γ、IL-12明显升高(P<0.01),Th2型细胞因子IL-5和IL-10在患者中检出率明显下降(P<0.01),TNF-α水平较治疗前显著下降(P<0.05)。治疗组对药物反应良好的患者,IL-2、IFN-γ、IL-12明显高于对药物反应不良者。结论脑囊虫病患者治疗后Th2型细胞因子反应减弱,而Th1型细胞因子反应增强,机体的保护性免疫应答已经开始恢复。

Objective To explore immunological mark and the outcome of disease after pharmacological treatment in human NCC with praziquantel.Methods 35 patients were treated with praziquantel for 6 months. Levels of serum IL 2, IFN γ, IL 12,IL 5,IL 10 and TNF αwere measured before and after treatment. Results Th1 type cytokines IL 2, IFN γand IL 12 were up regulated after treatment(P< 0.01).Levels of TNF αand Th2 type cytokines IL 5 and IL 10 were remarkable decreased after treatment(P< 0 01).The levels of IL 2, IFN γand IL 12 from the patients with good response to the treatment is higher than those with no response to the treatment.Conclusion Th1 type cytokines were up regulated while Th2 type cytokines were down regulated in the NCC patients treated with praziquantel. The protective immunity may be related to the Th1 cell activation.