摘要
目的 :探讨妊娠高血压综合征 (妊高征 )患者蛋白尿、肾功能与围产期结局的关系。方法 :测定 15 0例妊高征患者和 4 0例正常孕产妇的 2 4h尿蛋白定量、血清尿素氮 (BUN)、尿酸 (UA)、肌酐 (Cr)、钙 (Ca2 + )和血压水平。结果 :(1)妊高征患者分娩时间明显提前 ,早产儿发生率和围产儿病死率均明显高于正常妊娠组 (P <0 .0 1) ,新生儿体重则明显低于正常妊娠对照组 (P <0 .0 0 1)。 (2 )妊高征组血压、BUN、UA、Cr、2 4h尿蛋白量均明显高于正常妊娠组(P <0 .0 0 1) ,而白蛋白 (Alb)、Ca2 + 均明显低于正常妊娠组 (P <0 .0 0 1)。 (3)随着收缩压的升高和 2 4h尿蛋白量的增加 ,新生儿体重逐渐降低 (P <0 .0 0 1)。 (4 )随着 2 4h尿蛋白量的增加 ,分娩周数逐渐缩短 (P <0 .0 5 ) ,血压、BUN、UA、Cr均逐渐升高 (P <0 .0 0 1) ,而Alb和Ca2 + 则逐渐降低 (P <0 .0 0 1)。(5 )相关分析表明新生儿体重与分娩周数、Ca2 + 呈明显正相关 ,而与 2 4h尿蛋白量、SBp、BUN呈明显负相关 ;2 4h尿蛋白量与分娩周数、新生儿体重、DBp、BUN、UA、Alb、Ca2 + 等 7项指标呈明显相关性 ;BUN与分娩周数、新生儿体重、2 4h尿蛋白量、UA、Cr、Ca2 + 等 6项指标呈明显相关性 ;UA与分娩周数、2 4h尿蛋白量、BUN、Cr、Alb、Ca2 + 等 6项?
Objective:To investigate the correlation between proteinuria, renal function and perinatal outcomes in pregnancy-induced hypertension (PIH).Methods:24-hour urinary proteinuria excretion(24h-UPE), blood urea nitrogen (BUN),uric acid (UA),creatinine (Cr),calcium(Ca 2+ ) and blood pressure levels were measured in 150 patients with PIH and 40 women with normal pregnancy.Results:Patients with PIH delivered significantly earlier than normal pregnancy. Patients with PIH had more premature birth and higher neonatal mortality than normal pregnancy(P<0.01).Their infants had significantly lower birth weights than normal pregnancy(P<0.001).The levels of blood pressures,BUN,UA,Cr and 24h-UPE in patients with PIH were significantly higher than those in normal 24h-UPE (P<0.001),and levels of albumin (Alb) and Ca 2+ were significantly lower than that in normal pregnancy(P<0.001).Neonatal weight decreased significantly as the systolic blood pressure (SBp) and 24h-UPE increased(P<0.001).With the increasing of 24h-UPE,blood pressures,BUN,UA and Cr increased significantly(P<0.001), but gestational age at delivery,Alb and Ca 2+ decreased significantly (P<0.05,P<0.001).Neonatal weights had a positive correlation with gestational age at delivery and Ca 2+ levels, but had a negative correlation with levels of 24h-UPE,SBp and BUN.24-hour urine protein was associated with gestational age at delivery,neonatal weights,levels of diastolic blood pressure(DBp),BUN,UA,Alb and Ca 2+ levels.The BUN levels were associated with gestational age at delivery,neonatal weights,levels of 24-hour urine protein,UA,Cr and Ca 2+ .The UA levels were associated with gestational age at delivery,levels of 24-hour urine protein,BUN,Cr and Ca 2+ .The Ca 2+ levels were associated with gestational age at delivery, neonatal weights,levels of 24-hour urine protein,SBp, DBp,BUN,UA,Cr and Alb.Conclusion:The levels of blood pressure,24h-UPE, BUN,UA and Ca 2+ was associated with PIH and neonatal outcomes.They can be used as markers for clinical monitoring and are important for diagnosis and treatment of PIH and for improving the perinatal outcome.
出处
《中国中西医结合肾病杂志》
2004年第7期387-391,共5页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
广东省重大专项及重点计划项目 (No .B3 0 3 0 2 )
2 0 0 2年佛山市第二批重点科技攻关项目 (医学部分 )
关键词
妊娠高血压综合征
血压
蛋白尿
肾功能
围产期结局
Pregnancy induced hypertension Blood pressure Proteinuria Renal function Perinatal outcome