摘要
目的 研究早期使用大剂量纳洛酮注射液对重型颅脑损伤病人所产生的意识障碍的治疗效果及其作用机制。方法随机选取50例经过纳洛酮治疗的重型颅脑损伤病人作为治疗组,并按照接近治疗组患者的受伤机制及病情,选取50例未给予纳洛酮治疗的病人作对照组。通过对两组病人GCS计分的总分平均值以及睁眼、言语反应和运动反应的记分值进行统计学分析。结果 治疗前两组病人意识障碍程度无显著差异。治疗后治疗组意识障碍有明显改善,总分平均值、睁眼及运动反应得分值显著增加(P<0.05),而病人的言语反应分值增加不明显(P>0.05)。结论 早期使用大剂量纳洛酮对重型颅脑损伤病人所产生的意识障碍有较好的治疗效果。
Objective To study the effect of neurotic function defect and the mechanism using larger dose injection of nalosone hydrochlo-ride in early for serious brain injury.Methods The patients were randomly divided into 2 groups: treated group (n = 50, the patients were treated by larger dose injection of nalosone hydrochloride) and comparison group (n = 50, not treated by this medicine) .Traumatic mechanism and pathology were approach between 2 groups.The statistics analysis and study were purtted in average value of GCS's summation, goggle response, language, and body movement ability. Results The degree of consciousness obstacle didn't prominent difference before treatment between 2 groups (P > 0.05) .The consciousness, goggle response, body movement ability, average values of score were prominent decrease (P < 0.05) after treatment, but average values of language score were little decrease (P > 0.05) . Conclusion Using larger dose injection of nalosone hydrochloride on early had finer curative effect which the patients of serious brain injury had produced symptom of consciousness obstacle.
