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Tie2受体研究进展及其在抗肿瘤治疗中的应用 被引量：1

Research advances in Tie2 receptor and its use in anti-tumor treatment
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摘要 Tie2是胚胎血管发育和肿瘤血管形成都需要的内皮细胞酪氨酸激酶受体,血管生成素(Ang)是其配体。正常成人组织中,Ang/Tie2受体水平较低,用于维持成熟的血管结构;一般癌组织中Ang/Tie2的表达较为活跃。本文综述了Ang/Tie的结构和功能研究的最新进展,Ang/Tie2在血管形成中的重要调节作用,以及可溶性Tie2在治疗肿瘤方面的前景。 Tie2is an endothelial receptor tyrosine kinase that is required for both normal embryonic vascular development and tumor angiogenesis.Angiopoietin is its ligand.In normal adult tissue,the expression level of Ang /Tie2only can maintain mature vasculature,but in tumor tissue,it can achieve a high level.The last research advances about Ang /Tie2structure and function,Ang /Tie2modulating function in angiogenesis and using soluble Tie2to treat tumor,are mainly de-scribed in this paper.
作者 廖振林 侯利华 陈薇 童贻刚
机构地区 军事医学科学院微生物流行病研究所
出处 《生物技术通讯》 CAS 2004年第4期383-385,共3页 Letters in Biotechnology
基金 北京市自然科学基金项目(5022012)
关键词 TIE2 受体 血管生成素 肿瘤 调节作用 治疗 Tie2,receptor,angiopoietin,tumor
分类号 R392.1 [医药卫生—免疫学] R73 [医药卫生—肿瘤]
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参考文献25

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同被引文献5

  • 1Zhu Yiqian, Lee Chanhung, Shen Fanxia, et al. Angiopoietin - 2 facilitates vascular endothelial growth factor- induced angiogenesis in the mature mouse brain[J]. Stroke,2005,36(7) :1533 - 1537.
  • 2Bimer P, Schindl M, McNulty W. Hypoxia - inducible factor - 1 is a marker for an unfavorable prognosis in early stage invasive cervical cancer[J]. Cancer Res, 2000, 60: 4693.
  • 3T Hashimoto, Y Wu, JF Li, et al. Regulation of Tie2 expression by angiopoietin -potential feedback system[ J]. J Neurosurg Anesthesiol, 2004,16(4) :334.
  • 4Lin P, Buxton JA, Acheson A, et al. Anti - angiogenic gene therapy targeting the endothelium - specific receptor tyrosine kinas Tie2 [J]. Proc Nail Acad Sci USA, 1998, 95(15) : 8828.
  • 5陈立波,王国斌,郑启昌,杨镇.血管生成素-2基因及其受体Tie2在人肝癌组织的表达[J].中华外科杂志,2001,39(6):469-472. 被引量：18

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生物技术通讯
2004年 第4期

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