摘要
长期以来缺乏病毒体内感染的小动物模型是制约HIV 1研究取得突破性进展的一大障碍。研究者将胎儿的胸腺和胎肝组织移植到重症联合免疫缺陷 (SCID)小鼠体内 ,构建了SCID hu (Thy/Liv)人鼠嵌合模型。该模型具备正常功能性的人造血器官“Thy/Liv” ,较真实地模拟了HIV 1感染人胸腺后的状况 ,是研究HIV 1体内感染较成功且很有潜力的嵌合鼠模型。SCID hu (Thy/Liv)模型的构建使得在小型动物体内研究HIV的某些致病机制、临床前评价各种先导药物的体内抗HIV活性、评价新的治疗方案及寻求合适的基因治疗等成为可能 ,为在体内研究人造血系统和免疫系统的病理生理机能及人干细胞基因治疗提供了有力的工具 ,有广泛的应用前景。
A limitation in advancing the study of HIV-1 is the lack of a suitable small animal model system that allows for HIV-1 infection to be monitored.A mouse model of AIDS would be very useful because of it practicality and the ready availability of knowledge,reagents and immunogenetics.SCID-hu (Thy/Liv) mouse model,in which human fetal thymus and liver tissue are co-implanted into severe combined immunodeficient mice and resulting in a functional human hematopoietic organ (Thy/Liv),recapitulates the effects of HIV-1 infection in the human thymus.SCID-hu (Thy/Liv) mice are attractive and well-established small animal models for the study of HIV-1 infection in vivo.The humanized SCID mouse model would be served as valuable tools for in vivo studying pathogenesis of HIV,analysis of candidate anti-HIV drugs and vaccines prior to their clinical evaluation in human.
基金
国家高技术研究发展计划 ( 863计划 ) ( 2 0 0 3AA2 1914 2 )
中国科学院知识创新工程重要方向 (KSCX2 -SW -2 16)
云南省自然科学基金 ( 2 0 0 2C0 0 66M2 0 0 3C0 0 2 2R)资助项目
