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SARS病毒RNA二级结构及RNAi作用靶位的计算机预测

Computer Simulation of RNA Secondary Structures of SARS Virus and Prediction of Target Sites of RNAi Action
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摘要 该研究使用两个基于不同算法的RNA二级结构预测软件RNAstructure3.71和RNAdrawV1.1b2,通过对SARS冠状病毒BJ01和TOR02株的基因组序列的二级结构进行计算机初步模拟,得到可能用于RNAi作用药物设计的6个结构. In this research, the secondary structures of BJ01 and TOR02 isolates' SARS-Cov genome sequences are simulated with two software tools: RNAstructure 3.71 and RNAdrawV1.1b2, which are based on different algorithms to predict RNA secondary structures. Six potential structures have been obtained, which can be used in designing medicines by RNAi action.
作者 柳平英 刘志学 郭景康
机构地区 上海大学理学院 上海大学生命科学学院
出处 《上海大学学报（自然科学版）》 CAS CSCD 2004年第4期435-440,共6页 Journal of Shanghai University:Natural Science Edition
关键词 SARS冠状病毒 RNA二级结构 RNAi作用靶位 计算机预测 SARS-Cov RNA secondary structures RNAi acting targets computer prediction
分类号 Q752 [生物学—分子生物学]
  • 相关文献

参考文献17

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共引文献121

上海大学学报（自然科学版）
2004年 第4期

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