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牙龈卟啉菌蛋白酶的结构和作用 被引量：1

Structure and action of gingipain
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摘要 牙龈蛋白酶是牙龈卟啉菌的主要致病因子 ,因其对宿主蛋白的广泛活性受到了普遍关注。本文就牙龈蛋白酶的生化特征、基因结构、蛋白分子结构与作用的研究现状作一综述。 Porphyromonas gingivalis is implicated as etiologic agent in the pathogenesis of adult human periodontal diseases.Gingipains might act as the main virulence factors of Porphyromonas gingivalis .It has wide biological activities on the periodontal tissue proteins.So they attract more and more attention now.Therefore,we review the recent research about biochemical character、gene structure、protein structure and action of it.
作者 张凤秋 杨连甲 吴织芬
机构地区 第四军医大学口腔医学院
出处 《牙体牙髓牙周病学杂志》 CAS 2004年第6期352-354,共3页 Chinese Journal of Conservative Dentistry
关键词 牙龈卟啉菌 牙龈蛋白酶 基因序列分析 Porphyromonas gingivalis gingipain gene sequence analysis
分类号 R780.2 [医药卫生—口腔医学]
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参考文献17

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同被引文献9

  • 1Sheets SM,Potempa J,Travis J,et al.Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells.Infect Immun,2005,73(3):1543-1552.
  • 2Rangarajan M,Hashim A,Aduse-Opoku J,et al.Expression of Arg-Gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50.Infect Immun,2005,73(8):4864-4878.
  • 3Pathirana RD,O'Brien-Simpson NM,Brammar GC,et al.Kgp and RgpB,but not RgpA,are important for Porphyromonas gingivalis virulence in the murine periodontitis model.Infect Immun,2007,75(3):1436-1442.
  • 4Stathopoulou PG,Galicia JC,Benakanakere MR,et al.Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism.BMC Microbiol,2009,9(1):107-118.
  • 5Belibasakis GN,Bostanci N,Hashim A,et al.Regulation of RANKL and OPG gene expression in human gingival fibroblasts and periodontal ligament cells by Porphyromonas gingivalis:a putative role of the Arg-gingipains.Microb Pathog,2007,43(1):46-53.
  • 6Urnowey S,Ansai T,Bitko V,et al.Temporal activation of anti-and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen,Porphyromonas gingivalis:potential role of bacterial proteases in host signalling.BMC Microbiol,2006,6(1):26-40.
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  • 8侯建霞,Peter M Loomer,Barron Hong.牙龈卟啉单胞菌超声提取物对人牙周膜干细胞骨向分化的影响[J].现代口腔医学杂志,2007,21(6):603-605. 被引量：12
  • 9张凤秋,杨连甲,吴织芬,金岩,周鹏.牙龈卟啉菌牙龈蛋白酶K催化结构域的克隆及其在大肠杆菌中的表达[J].口腔医学研究,2003,19(4):244-246. 被引量：5

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牙体牙髓牙周病学杂志
2004年 第6期

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