摘要
AIM: To study the alteration of nuclear matrix proteins (NMPs) in gastric cancer. METHODS: The NMPs extracted from 22 cases of gastric cancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software. RESULTS: Compared with normal gastric tissue, the expression of 30 ku and 28 ku NMPs in gastric cancer decreased significantly (P=-0.002, P=0.001, P<0.05). No significant difference was found in the expression of the two NMPs between the various differentiated grades (P=0.947, P=-0.356) and clinical stages of gastric cancer (P=0.920, P=-0.243, P＞0.05). CONCLUSION: The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.
AIM:To study the alteration of nuclear matrix proteins (NMPs)in gastric cancer. METHODS:The NMPs extracted from 22 cases of gastric cancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software. RESULTS:Compared with normal gastric tissue,the expression of 30 ku and 28 ku NMPs in gastric cancer decreased significantly(P=0.002,P=0.001,P<0.05).No significant difference was found in the expression of the two NMPs between the various differentiated grades (P=-0.947,P=-0.356)and clinical stages of gastric cancer (P=0.920,P=0.243,P>0.05). CONCLUSION:The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.
基金
Supported by the National Natural Science Foundation of China,No.39170440
