解酒灵的急性毒性和遗传毒性评价

Study on Acute Toxicity and Genotoxicity of the JIEJIULING

目的 评价新的护肝解酒液解酒灵的安全性。方法 采用SD大鼠经口急性毒性试验、Ames试验、小鼠微核试验、小鼠精子畸变试验对其急性毒性和遗传毒性进行了测试。结果 本检品对小鼠的急性经口LD50 大于 12 5g/kg bw ,判属实际无毒类。Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验 3项遗传毒性试验均为阴性结果 ,表明本检品无遗传毒性。结论 解酒灵属实际无毒和无遗传毒性的护肝解酒液 ,具有保护肝免受酒精损害的功能。

Objective To evaluate the security of JIEJIULING which protects liver against alcoholism in a kind of liguid.Methods SD mice were tested for JIEJIULING by the acute toxicity test,Ames test,Micronuclei test of bone marrow cell and sperm shape abnormality test.Results The results showed that the LD 50 of JIEJIULING was more than 12.5 g/kg body weight,and was not found any genotoxicity in the three mutagenic tests.Conclusion JIEJIULING is no toxicity and genotoxicity.