微重力导致航天员骨质疏松的研究进展

Researches of microgravity induced osteopenia in cosmonauts

目的 概述近年来有关微重力导致航天员骨质疏松的研究进展。 资料来源与选择 国内外相关文献 4 6篇。 资料综合 详细论述了微重力对骨组织计量学、生化和骨发育的影响 ,地面模拟微重力的人体卧床实验和动物尾部悬吊实验 ,微重力诱导骨质减少的可能机制以及对抗措施等方面的问题。 结论 空间飞行中微重力状态下 ,骨形成减少 ,导致主要是 1G环境下的负荷骨的骨质减少。由于空间实验的数量有限和局限性 ,所以还不能对微重力影响骨的确切效应下最后的结论。

Objective To summarize the researches of microgravity induced osteopenia in recent years. Literature resource and selection The related published articles in this field home and abroad. Literature quotation Forty six references were cited. Literature synthesis The changes of bone morphometry,biochemistry and development of bone in microgravity condition and its possible mechanism and countermeasures were introduced. Conclusions The mechanisms of microgravity induced osteopenia were not fully clarified, further investigation is needed.