丹参注射液对颈椎病家兔血液流变性的影响

Effects on Hemorrheology of Salvia Miltiorrhizae Injection on Rabbit's Cervical Spondylosis

目的观察家兔颈椎间盘退变过程中血液流变性变化和丹参注射液对这些变化的影响。方法通过破坏家兔颈椎动、静力平衡 ,建立家兔颈椎间盘退变的模型。60只兔子 ,随机分成3组 ,颈椎间盘退变组(A)40只 ,分4个亚组(A1、A2、A3、A4) ,即为造模后1、3、5、7月组 ,每组各10只 ;退变加丹参治疗组(B)10只 ,造模后饲养6个月后 ,每日腹腔内注射丹参注射液2ml,1个月后处死 ;正常对照组(C)10只。通过测定血液流变学 (全血低切黏度、高切黏度、血浆黏度、红细胞比容、血沉、血浆纤维蛋白原 ) ,比较各组之间的差异。结果7月组(A4)家兔全血高切黏度、低切黏度、血浆黏度、血沉与正常对照组 (C)比较有极显著差异(P<0.01) ,红细胞比容同正常组比较P<0.05;丹参治疗组(B)家兔全血高切黏度、低切黏度、血沉与A4组比较P<0.01 ,红细胞比容同A4组比较(P<0.05) ,以上均有显著性差异。结论丹参能改善家兔血液流变性和微循环的灌注 ,促进组织的修复 。

Objective Observe the change of hemorheology in the process of rabbit's cervical intervertebral discs deterioration,and impacts salvia miliorrihizae injection has on those changes.Methods Set up the model of rabbit's cervical intervertebral discs deterioration by destroying rabbit's dynamostatic balance.Sixty rabbits were at random divided into three groups.In the cervical intervertebral discs deterioration group(A)there were forty rabˉbits,which were divided into four subgroups(A1、A2、A3、A4),i.e.after setting up the model month1、month3、month5、month7group in which there were ten rabbits respectively;Group(B):there are ten rabbits with cervical intervertebral discs deterioration but treated with salvia miliorrihizae Injection.after setting up the model these rabˉbits were raised six months,every day they were injected salvia miliorrihizae Injection2ml into their abdominal cavity,they were executed one month later;there were ten rabbits in the normal contrast group(C).We measured hemorheology(bvl,bvh,pv,HCT,ESR,FB),compared the differences between the groups.Results Compared A4group to C group,it was P<0.01in the terms of the whole blood viscosity(bvh,bvl)、plasma viscosity(pv)and ESR,it was P<0.05in terms of HCT,all the above comparisons indicated significant differences;in terms of fibrinogen(FB),it was P>0.05,which indicated no significant difference.Compared B group to A4group,it was P<0.01in the terms of bvh、bvl and ESR,it was P<0.05in terms of HCT,all the above comparisons inˉdicated significant differences;in terms of pv and FB,it was P>0.05,which indicated no significant differˉence.Conclusions Salvia miltiorrhizae can improve rabbit's hemorheology and irrigation of micro circulation,proˉmote tissue's repair and reproduction,put off and hinder retrogression of cervical intervertebral discs.