参附注射液对中晚期肿瘤患者微循环及血液流变性的影响

Effects of Microcirculation and Hemorrheology in Patients with Progressing and Terminal Tumors

目的观察参附注射液 (SF)对中晚期肿瘤患者微循环及血液流变性的影响。方法将60例中晚期肿瘤患者配对分为两组 ,对照组30例予放射治疗 ,每次2Gy,每周5次 ,共6周。治疗组30例予放疗联合SF治疗 ,每日1次 ,每次50ml,每周5次 ,共6周。两组分别于治疗前、治疗后检测甲襞微循环及血液流变学指标。结果肿瘤患者的甲襞微循环以血管囊状扩张、毛细血管血流减慢、红细胞聚集等改变最显著 ,治疗组能明显降低流态积分、综合积分 (P<0 .01) ,从而改善微血管状态 ;肿瘤患者存在全面的血液流变学异常 ,其中血浆黏度、红细胞聚集指数 (RE)、纤维蛋白原 (Fg)明显增高 ,SF可显著降低全血低切黏度、RE及Fg(P<0.01) ,改善血液流变性。结论SF可改善中晚期肿瘤患者的微循环及血液流变学异常 。

Objective To evaluate the effects of microcirculation and hemorrheology by Injection of Shenfu(SF)on patients with progressing and terminal tumor.Methods60patients suffered from progressing and terminal tumors were divided into two groups randomly.30patients in the control group received radiotherapy of2Gy five times a week for six weeks.30patients in the treatment group received radiotherapy as well as50ml SF therapy five times a week for six weeks.Nail microcirculation and hemorrheology were performed in all patients before and after the treatments respectively.Results The major manifestations of nailfold microcirculation in patients were cystiform blood vessels,slowing stream in capillary,aggregatlon,etc.The blood flow condition and total integral value in the treatment group were significantly decreased(P<0.01).The patients had various abnormalities in hemorrheology.The levels of serum viscosity,aggregation rate of erythrocyte(RE)and fibrinogen(Fg)hightened.SF lessened the levels of blood viscosity,RE and Fg(P<0.01)and then ameliorated the Hemorrheology.Conclusions SF can rectify the abnormality of microcirculation and hemorrheology in patients with progressing and terminal tumor.SF may be an effective avenue of prevention and cure of tumors.