骨形态发生蛋白-9临床研究进展

The Advances in the Clinical Research of Bone Morphogenetic Protein-9

骨形态发生蛋白-9(BMP-9)可以诱导间充质细胞增殖及向软骨细胞转化;促进胚胎鼠原始神经元的乙酰胆碱(ACh)的合成及诱导胆碱乙酰基转移酶和乙酰胆碱小泡转运体的表达;BMP-9对造血干细胞有双向调节作用;BMP-9作用于肝网状内皮系统,在调节糖脂代谢方面发挥了一定的作用。

Bone morphogenetic protein-9 induces the proliferation of the mesenchymal stem cells and plays an important role in chondrogenesis. It also induces the expression of choline acetyltrans-ferase and transportation of the vesicular acetylcholine ( ACH) and upregulates Ach synthesis. BMP-9 plays a dual part in regulating proliferation of primitive hemopoietic progenitor cells. BMP-9 acts as a potential mediator in the hepatic reticuloendothelial system, thereby regulating the glucose and lipid metabolism.