三种方案治疗晚期大肠癌近期疗效比较

Immediate effects of three different regimens in advanced colorectal cancers

目的 :比较 5 FU/LV、L OHP +5 FU/LV及CPT 11+5 FU/LV治疗晚期大肠癌的疗效和毒副反应。方法 :采用三种方案对 6 5例患者进行研究 ,3周为一个疗程。 5 FU/LV方案为LV 2 0 0mg/d ,iv 2小时 ,第 1～ 5天 ;5 FU5 0 0mg/d ,iv第 1～ 5天 ;L OHP +5 FU/LV方案为L OHP 130mg/m2 iv第 1天 ,5 FU/LV用法同上 ;CPT 11+5 FU/LV方案为CPT 11180mg/m2 30分钟第 1天 ,5 FU/LV用法同上。至少化疗 2个疗程后进行评价。结果 :三种方案总体疗效分别为 13.33%、2 1.2 1%、11.76 % ;总体恶心、呕吐发生率分别为 4 0 .0 0 %、39.39%、17.6 5 % ;腹泻发生率分别为 13.33%、6 .0 6 %、2 9.4 1% ;骨髓抑制发生率分别为 2 6 .6 7%、2 4 .2 4 %、35 .2 9% ;神经毒性发生率分别为 0、15 .15 %、0 ;三种方案间均无显著性差异 (P >0 .0 5 )。结论 :三种方案治疗晚期大肠癌的近期疗效无明显差别 ,毒副反应发生率低 ,耐受好 。

Purpose:To compare the effect and toxicity of 5-FU/LV, L-OHP+5-FU/LV, CPT-11+5-FU/LV in advanced colorectal cancers.Methods:65 patients were entered into the study. All the regimens were repeated every 3 weeks. 5-FU/LV regimen was given as LV 200mg/d,iv 2h,d 1-5; 5-FU 500 mg/d, iv d 1-5. L-OHP+5-FU/LV regimen was given as L-OHP 130mg/m 2 iv d 1, and 5-FU/LV same to the above. CPT-11+5-FU/LV regimen was given as CPT-11 180mg /m 2 30min d 1 and 5-FU/LV same to the above. Results:The overall response rate was 13.33%, 21.21%, 11.76% respectively (P>0.05). The overall rate of nausea/vomiting was 40.00% ,39.39%,17.65% respectively(P>0.05); the rate of diarrhea was 13.33%,6.06%,29.41% respectively(P>0.05); the rate of bone marrow depression was 26.67% ,24.24%,35.29% respectively (P>0.05) and the rate of cold related dysesthesia was 0,15.15%,0 respectively (P>0.05).Conclusions:There was no difference in terms of both effect and toxicity among the three regimens. All of them were effective and could be well tolerated by advanced colorectal cancer patients.