吉西他滨联合氟尿嘧啶治疗晚期肝外胆管癌

Advanced cholangiocarcinoma treated with gemcitabine combined with 5-FU: An initial study of short-term therapeutic effect

目的 :观察吉西他滨 (健择 )联合氟尿嘧啶治疗晚期肝外胆管癌的近期疗效。方法 :2 1例晚期胆管癌患者采用GLF方案化疗 :健择 10 0 0mg/m2 ,静脉滴注 30～ 6 0分钟 ,第 1,8天给药。亚叶酸钙 2 0 0mg/m2 ,静脉滴注 ,第 1～ 5天。氟尿嘧啶 6 0 0mg/m2 ,静脉滴注 2小时 ,第 1～ 5天。 2 1天为一个周期。结果 :2 1例中无 1例达完全缓解 ,部分缓解 5例 (2 3.8% ) ,稳定 8例 (38.1% )。 12例 (5 7.14 % )患者疼痛得到缓解 ,生活质量提高。结论

Purpose:To observe the therapeutic effect of gemcitabine combined with 5-FU for the treatment of advanced cholangiocarcinoma. Methods:21 patients were given gemcitabine and 5-FU intravenously. Results:There was no complete response .The partial response rate was 23.8% and SD,38.1%.12 patients(57.14%) had amelioration of pain and improvement in quality of life.The toxicity was low and tolerable. Conclusions:Gemcitabine combined with 5-FU was an effective and safe regimen for treating advanced cholangiocarcinoma and worthy of further evaluation.