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乳腺癌耐药蛋白的研究进展 被引量：1

Research advances in breast cancer resistance protein (BCRP)
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摘要 乳腺癌耐药蛋白 (BCRP)是新近发现的一种肿瘤耐药相关蛋白 ,与P gp和多药耐药相关蛋白 (MRP)同属ABC转运蛋白超家族。本文对BCRP的发现、基因表达特征、与造血干细胞分化的关系。 WTBZ]Breast cancer resistance protein (BCRP) is a recently discovered half-transporter belonging to the ABC transporter superfamily as P-glycoprotein(P-gp) and multiple resistance protein (MRP). The latest research results concerned BCRP on construction features of gene, relationship to differentiation of hemopoietic stem cell and correlated transport substrates were reviewed in the article and it's clinical significance was mentioned at the same time.
作者 刘晓健 孙孟红 施达仁
机构地区 复旦大学附属肿瘤医院病理科
出处 《中国癌症杂志》 CAS CSCD 2004年第3期286-288,共3页 China Oncology
关键词 多药耐药 乳腺癌 基因表达 multidrug resistance breast cancer gene expression
分类号 R730.53 [医药卫生—肿瘤]
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参考文献30

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  • 2Diestra JE, Scheffer GL, Izquierdo MA, et al. Frequent expression of the multi-drug resistance-associated protein,BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin- embedded material[J].J Pathol, 2002, 198(2):213-
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同被引文献9

  • 1袁建辉,贺智敏,余艳辉,陈主初.Tet调控的乳腺癌耐受蛋白表达细胞系的建立及功能研究[J].癌症,2004,23(10):1127-1133. 被引量：7
  • 2Lemos G,Jansen G,Peters GJ.Drug transporters:recent advances concerning BCRP and tyrosine kinase inhibitors[J].Br J Cancer,2008,98(5):857-862.
  • 3Sarkadi B,Homolya L,Szakacs G,et al.Human multidrug resistance ABCB and ABCG transporters:participation in a chemoimmunity defense system[J].Physiol Rev,,2006,86(4):1179-1236.
  • 4Hu LL,Wang XX,Chen X,et al.BCRP gene polymorphisms are associated with susceptibility and survival of diffuse large B-cell lymphoma[J].Carcinogenesis,2007,28(8):1749-1744.
  • 5Krishnamurthy P,Ross DD,Nakanishi T,et al.The stem cell marker bcrp/abcg2 enhances hypoxic cell survival through interactions with heme[J].J Biol Chem,2004,279(23):24218-24225.
  • 6Ishikawa T,Ikegami Y,Sano K,et al.Transport mechanism-based drug molecular design:novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cclls[J].Curt Pharm Des,2006,12(3):313-325.
  • 7van den Heuvel-Eibrink MM,van der Holt B,Burner AK,et al.CD34-related coexpression of MDR1 and BCRP in&cares a clinically resistant phenotype in padents with acute myeloid leukemia (AML) of older age[J].Ann Hematol,2007,86(5):329-337.
  • 8彭向前,张文会,李军.氧化苦参碱逆转多药耐药细胞系K562/A02耐药性的研究[J].中国肿瘤临床,2008,35(19):1127-1130. 被引量：21
  • 9张翠宁,刘晓秋,韩英,赵阿津,宋保民.脉冲磁场逆转乳腺癌细胞多药耐药性的作用研究[J].中国肿瘤临床,2008,35(21):1241-1243. 被引量：7

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中国癌症杂志
2004年 第3期

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