乳腺癌前哨淋巴结状态与CD44V6相关研究

Study the relationship between the status of sentinel lymph node and expression of CD44V6 in breast cancer

目的 探讨乳癌前哨淋巴结状况与其CD44V6表达的相互关系。方法采用S-P法对48例已获得前哨淋巴结乳腺癌患者原发灶进行CD44v6表达的研究。结果 前哨淋巴结阳性患者原发灶CD44v6阳性率(92.5％)明显高于前哨淋巴结阴性患者(14.3％),P<0.01。前哨淋巴结及腋淋巴结均阳性患者原发灶CD44V6阳性率(100％)明显高于前哨淋巴结及腋淋巴结均阴性患者(23.5％),P<0.001。结论 前哨淋巴结状态与CD44V6阳性表达呈正相关。两者相结合起来分析可以更全面地反映乳腺癌转移规律及腋淋巴结状态。

Objective To study the relationship between sentinel lymph node and expression of CD44V6 in breast cancer. Methods The CD44V6 expression in 48 samples that with sentinel of breast cancer tissue were studied by immunohistocheical S-P technique. Results It was found that the expression of CD44V6 in cases with sentinal lymph node metastases were singificantlly than those without metastases (P<0.001). The expression of CD44V6 of CD44V6 in cases with sentinal and axillary lymph node metastases were significantly than those without metastasis(P<0.001). Conclusion Sentinal lymph node status was closely related with the expression of CD44V6 in breast cancer. Their combination more acuretaly predict the rules of breast cancer metastasis and status of the axillary node.