肌力失衡与后柱失稳大鼠颈椎病模型的研究

Study on the Models of Cervical Spondylosis of Muscle Imbalance and Posterior Column Instability in Rats

目的 :对肌力失衡与后柱失稳大鼠颈椎病模型进行研究。方法 :SD大鼠 (6 0只 )随机分为对照组 (2 0只 )、肌力失衡组 (2 0只 )和后柱失稳组 (2 0只 ) ,每组又分 2个月和 4个月组 ,各组 10只。建立两组不同的颈椎病模型后 ,通过X线影像评分和斜板实验评价运动功能情况。结果 :X线影像分析 :对照组生理弯曲存在 ,椎间隙无异常 ,未见骨赘形成 ,肌力失衡组和后柱失稳组有不同程度的生理弯曲消失 ,椎间隙变窄 ,骨赘形成 ,钩椎关节和关节突关节增生硬化。斜板实验运动功能评价 ,肌力失衡组和后柱失稳组的肌力有不同程度的下降。对照组 2、 4个月间无统计学意义 (P >0 .0 5 ) ,肌力失衡组和后柱失稳组 2、 4个月间有统计学意义 (P <0 .0 1) ,而肌力失衡组与后柱失稳组无统计学意义 (P >0 0 5 )。结论 :肌力失衡与后柱失稳均可致大鼠颈椎病发生 。

Objective:To study the models of cervical spondylosis of muscle imbalance and posterior column instability in rats. Methods: Sixty SD rats were randomly divided into control, muscle imbalance and posterior column instability groups, which were subdivided into group of 2 and 4 months, ten rats in each group. The X-ray film and motion function of oblique board test were evaluated. Results: In control group, the X-ray film showed nature curve, normal vertebral clearance, no osteosis spur and ossify in Luschka joint and joint process. But in muscle imbalance and posterior column instability groups, disappeared or stiff nature curve, stenosis vertebral clearance, osteosis spur formed, ossify or sclerosis were emerged. Compared with control group in oblique board test, the muscle force decreased in muscle imbalance and posterior column instability groups. There was no significant difference in control group of 2 and 4 months(P>0.05), but in muscle imbalance and posterior column instability groups, there was significant difference in 2 and 4 months(P<0.01). Conclusion: Cervical posterior column instability and muscle imbalance can all result in cervical spondylosis, both muscle force balance and posterior column are important in maintaining cervical stability.