摘要
目的 :探讨甘草酸二铵注射液对恶性肿瘤患者全身化疗所致肝损害的防治效果。方法 :10 0例患者采用自身对照 ,每例用同一化疗方案连续化疗 2周期 ,其中一周期单纯化疗 ,另一周期化疗同时加用甘草酸二铵注射液 ;观察化疗后肝功能变化。结果 :两周期化疗后谷氨酸转氨酶升高分别为 15 0 % ,5 0 % (χ2 =5 5 5 6 ,P =0 0 18) ;谷氨酰胺转移酶升高13 0 % ,5 0 % (χ2 =3 90 7,P =0 0 4 8)。加用甘草酸二铵周期的肝功能损害的发生率明显减少。结论
Objective :To evaluate the effect of Diammonii Glycyrrhizinatis in preventing liver damage caused by chemotherapeutic agents.Methods:Using cross-over study method,100 patients with malignant tumor were recruited in this clinical trial.Diammonii Glycyrrhizinatis was used as self-control in the previous or next course of chemotherapy in the same patient.Each patient was treated with chemotherapy alone for one cycle,and chemotherapy in combination with Diammonii Glycyrrhizinatis injection for the other.The change of liver function was observed.Results:The incidences of ALT elevation were 15.0% and 5.0%,respectively(χ 2=5.556,P=0.018),and the corresponding rates of GGT elevation were 13.0% and 5.0%,respectively(χ 2=3.907,P=0.048)in chemotherapy and combination groups.The abnormality of liver function was less in the combination group.Conclusion:Diammonii Glycyrrhizinatis is effective for preventing hepatic damage induced by chemotherapeutic agents.
出处
《汕头大学医学院学报》
2004年第2期78-79,共2页
Journal of Shantou University Medical College
关键词
甘草酸二铵注射液
预防
化疗
肝功能异常
恶性肿瘤
Neoplasm,Drug Therapy
Liver Disease,Chemically Induced
Glycyrrhizic Acid,Therapeutic Use