月经和生育因素对妇女肺癌危险度的影响

Influence of menstrual and reproductive factors on the risk of lung cancer

目的 验证雌激素可能对肺癌危险度产生的影响 方法 1994～1998年在甘肃省陇东地区进行了一项女性人群的病例对照研究,分析了月经和生育因素与肺癌危险度之间的关系。病例组为109例女性肺癌病例和435名女性为对照组,对照组是根据人口调查资料,按年龄和地区与病例频数匹配得到的。结果 初潮年龄晚(趋势检验P=0.015)、绝经年龄晚(趋势检验P=0.074)的女性,其肺癌比值比较低。结论 尽管有局限性,上述发现表明雌激素在女性肺癌病因学中起到一定作用。

Objective Hypothesis showed that women have higher risks of lung cancer than men when given similar levels of tobacco exposure, implying that sex-related hormones might have a role to play. The study is to identify the influence of female hormones on risk of lung cancer. Methods We evaluated the association between lung cancer risk and menstrual/reproductive factors on a subse t of self- responding females in a population based case-control study in Eastern Gansu, 1994-1998. The analysis included 109 lung cancer cases and 435 controls selected from the census list and matched to cases on age and prefecture. Results Odds ratios were lower for later ages at menarche (trend, P=0.015) and later ages at menopause (trend, P=0.074). Conclusion Despite limitations, these findings suggested a possible role related to hormones in the etiology of lung cancer in females.